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    RAET1G retinoic acid early transcript 1G [ Homo sapiens (human) ]

    Gene ID: 353091, updated on 9-Dec-2024

    Summary

    Official Symbol
    RAET1Gprovided by HGNC
    Official Full Name
    retinoic acid early transcript 1Gprovided by HGNC
    Primary source
    HGNC:HGNC:16795
    See related
    Ensembl:ENSG00000203722 MIM:609244; AllianceGenome:HGNC:16795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ULBP5
    Summary
    This gene encodes a member of the major histocompatibility complex (MHC) class I family of proteins. Although the encoded protein includes C-terminal transmembrane and cytoplasmic domains, proteolytic processing results in the removal of these domains and subsequent tethering to the plasma membrane by a glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is one of several related ligands of the natural killer group 2, member D (NKG2D) receptor, which functions as an activating receptor in innate and adaptive immunity. This gene is present in a gene cluster on chromosome 6. [provided by RefSeq, Jul 2015]
    Expression
    Biased expression in esophagus (RPKM 1.3), adrenal (RPKM 0.9) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RAET1G in Genome Data Viewer
    Location:
    6q25.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (149916878..149923121, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (151116222..151122465, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (150238014..150244257, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RAET1E antisense RNA 1 Neighboring gene multimerin 2 pseudogene Neighboring gene retinoic acid early transcript 1F (pseudogene) Neighboring gene ReSE screen-validated silencer GRCh37_chr6:150238439-150238724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150246453-150246988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150246989-150247523 Neighboring gene uncharacterized LOC105378052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:150259106-150259796 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:150259797-150260487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17672 Neighboring gene UL16 binding protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 (SF2) Nef downregulates RAET1G (ULBP5); downregulation is dependent upon residues G2 and F195 and a di-lysine motif in Nef as shown in A3.01 T cells and HeLa TZM-bl cells PubMed
    Vpu vpu HIV-1 (NL4-3) Vpu downregulates RAET1G (ULBP5); downregulation is dependent upon amino acids R30/K31, V25/Y29, the acidic di-leucine motif in Vpu helix 2 as shown in A3.01 T cells and HeLa TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables natural killer cell lectin-like receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    UL-16 binding protein 5
    Names
    retinoic acid early transcript 1G protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001788.4NP_001001788.2  UL-16 binding protein 5 preproprotein

      See identical proteins and their annotated locations for NP_001001788.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as RAET1G1) represents the longer transcript and encodes the protein.
      Source sequence(s)
      AY172579, AY172580, HY165961
      Consensus CDS
      CCDS43514.1
      UniProtKB/Swiss-Prot
      Q6H3X2, Q6H3X3
      Related
      ENSP00000356329.2, ENST00000367360.7
      Conserved Domains (1) summary
      cl08246
      Location:29198
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RNA

    1. NR_130110.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as RAET1G2) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AY172580, HY165961

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      149916878..149923121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535800.4XP_011534102.1  UL-16 binding protein 5 isoform X2

      Conserved Domains (1) summary
      cl08246
      Location:29198
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    2. XM_017010831.3XP_016866320.1  UL-16 binding protein 5 isoform X1

      Conserved Domains (1) summary
      cl08246
      Location:29198
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    3. XM_047418729.1XP_047274685.1  UL-16 binding protein 5 isoform X3

      UniProtKB/TrEMBL
      Q4V9S8
      Related
      ENSP00000356330.2, ENST00000367361.6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      151116222..151122465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355347.1XP_054211322.1  UL-16 binding protein 5 isoform X2

    2. XM_054355346.1XP_054211321.1  UL-16 binding protein 5 isoform X1

    3. XM_054355348.1XP_054211323.1  UL-16 binding protein 5 isoform X3

      UniProtKB/TrEMBL
      Q4V9S8