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    RAET1L retinoic acid early transcript 1L [ Homo sapiens (human) ]

    Gene ID: 154064, updated on 9-Dec-2024

    Summary

    Official Symbol
    RAET1Lprovided by HGNC
    Official Full Name
    retinoic acid early transcript 1Lprovided by HGNC
    Primary source
    HGNC:HGNC:16798
    See related
    Ensembl:ENSG00000155918 MIM:611047; AllianceGenome:HGNC:16798
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ULBP6; RAET1H
    Summary
    RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins are anchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in esophagus (RPKM 15.6) and skin (RPKM 1.0) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RAET1L in Genome Data Viewer
    Location:
    6q25.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (150018334..150025532, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (151217707..151224927, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (150339470..150346668, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene basic transcription factor 3 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17673 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:150312121-150312704 Neighboring gene retinoic acid early transcript 1K (pseudogene) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150327472-150328187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25270 Neighboring gene retinoic acid early transcript 1M (pseudogene) Neighboring gene PHB1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 (SF2) Nef downregulates RAET1L (ULBP6); downregulation is dependent upon residues G2 and F195 and a di-lysine motif in Nef as shown in A3.01 T cells and HeLa TZM-bl cells PubMed
    Vpu vpu HIV-1 (NL4-3) Vpu downregulates RAET1L (ULBP6); downregulation is dependent upon amino acids R30/K31, V25/Y29, the acidic di-leucine motif in Vpu helix 2 as shown in A3.01 T cells and HeLa TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    UL16-binding protein 6
    Names
    UL16 binding protein 6
    retinoic acid early transcript 1H
    retinoic acid early transcript 1L protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130900.3NP_570970.2  UL16-binding protein 6 precursor

      See identical proteins and their annotated locations for NP_570970.2

      Status: VALIDATED

      Source sequence(s)
      AL355497, AY039682, DA442768
      Consensus CDS
      CCDS5224.1
      UniProtKB/Swiss-Prot
      A3KME4, Q5VY80, Q8TE74
      UniProtKB/TrEMBL
      Q8IZX9
      Related
      ENSP00000356310.1, ENST00000367341.6
      Conserved Domains (1) summary
      cl08246
      Location:29198
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      150018334..150025532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      151217707..151224927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)