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    sigX RNA polymerase sigma factor SigX [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878527, updated on 24-Aug-2024

    Summary

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    Gene symbol
    sigX
    Gene description
    RNA polymerase sigma factor SigX
    Locus tag
    PA1776
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (1920568..1921065)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene outer membrane porin F Neighboring gene uroporphyrin-III C-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The absence of SigX results in impaired carbon metabolism and membrane fluidity in Pseudomonas aeruginosa. Fléchard M, et al. Sci Rep, 2018 Nov 21. PMID 30464317, Free PMC Article
    2. A proteomic approach of SigX function in Pseudomonas aeruginosa outer membrane composition. Duchesne R, et al. J Proteomics, 2013 Dec 6. PMID 24332064
    3. Transcription of the oprF gene of Pseudomonas aeruginosa is dependent mainly on the SigX sigma factor and is sucrose induced. Bouffartigues E, et al. J Bacteriol, 2012 Aug. PMID 22685281, Free PMC Article
    4. Influence of a putative ECF sigma factor on expression of the major outer membrane protein, OprF, in Pseudomonas aeruginosa and Pseudomonas fluorescens. Brinkman FS, et al. J Bacteriol, 1999 Aug. PMID 10438740, Free PMC Article
    5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Altogether, these data suggest that SigX is indirectly involved in carbon catabolite repression regulation, possibly via its effects on membrane integrity and fluidity.
      Title: The absence of SigX results in impaired carbon metabolism and membrane fluidity in Pseudomonas aeruginosa.
    2. The data presented here suggest that SigX is involved in the outer membrane protein composition, and could be linked to a regulatory network involved in OM homeostasis.
      Title: A proteomic approach of SigX function in Pseudomonas aeruginosa outer membrane composition.
    3. oprF transcription was increased in response to low NaCl or high sucrose concentrations, and this induced transcription was strongly impaired in the absence of SigX.
      Title: Transcription of the oprF gene of Pseudomonas aeruginosa is dependent mainly on the SigX sigma factor and is sucrose induced.
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    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables sigma factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA polymerase sigma factor SigX
    NP_250467.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      1920568..1921065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_250467.1 RNA polymerase sigma factor SigX [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_250467.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q9I2W5
      Conserved Domains (1) summary
      PRK09640
      Location:2 → 165
      PRK09640; RNA polymerase sigma factor SigX; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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