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    ptxS transcriptional regulator PtxS [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 877811, updated on 24-Aug-2024

    Summary

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    Gene symbol
    ptxS
    Gene description
    transcriptional regulator PtxS
    Locus tag
    PA2259
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (2487856..2488878)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene paerucumarin biosynthesis protein PvcC Neighboring gene paerucumarin biosynthesis protein PvcD Neighboring gene HTH-type transcriptional regulator PtxR Neighboring gene hypothetical protein Neighboring gene 2-ketogluconate kinase Neighboring gene 2-ketogluconate transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional analysis of the Pseudomonas aeruginosa toxA regulatory gene ptxR. Colmer-Hamood JA, et al. Can J Microbiol, 2006 Apr. PMID 16699585
    2. The Pseudomonas aeruginosa global regulator MvaT specifically binds to the ptxS upstream region and enhances ptxS expression. Westfall LW, et al. Microbiology (Reading), 2004 Nov. PMID 15528665
    3. Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS. Daddaoua A, et al. PLoS One, 2012. PMID 22844393, Free PMC Article
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PtxS modulates PtxR activity in response to 2-ketogluconate by complex formation in solution in the case of the P(toxA) promoter, or via the formation of a DNA loop as in the regulation of gluconate catabolic genes
      Title: Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS.
    2. results suggest that MvaT positively regulates ptxS expression by binding specifically to the ptxS upstream region
      Title: The Pseudomonas aeruginosa global regulator MvaT specifically binds to the ptxS upstream region and enhances ptxS expression.
    3. Results indicate that negative regulation of ptxR expression by PtxS does not occur through the PtxS binding site within the ptxR-ptxS intergenic region.
      Title: Transcriptional analysis of the Pseudomonas aeruginosa toxA regulatory gene ptxR.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcriptional regulator PtxS
    NP_250949.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      2487856..2488878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_250949.1 transcriptional regulator PtxS [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_250949.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3M5ET15
      Conserved Domains (2) summary
      smart00354
      Location:12 → 82
      HTH_LACI; helix_turn _helix lactose operon repressor
      cd06283
      Location:72 → 333
      PBP1_RegR_EndR_KdgR-like; ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR
    Nucleotide Protein
    Heading Accession and Version

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