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    wbpD UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882593, updated on 24-Aug-2024

    Summary

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    Gene symbol
    wbpD
    Gene description
    UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase
    Locus tag
    PA3156
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (3540210..3540785, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene O-antigen translocase Neighboring gene B-band O-antigen polymerase Neighboring gene UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase Neighboring gene acetyltransferase Neighboring gene UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase Neighboring gene UDP-N-acetyl-d-glucosamine 6-dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence that WbpD is an N-acetyltransferase belonging to the hexapeptide acyltransferase superfamily and an important protein for O-antigen biosynthesis in Pseudomonas aeruginosa PAO1. Wenzel CQ, et al. Mol Microbiol, 2005 Sep. PMID 16102001
    2. Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1. Larkin A, et al. Biochemistry, 2009 Jun 16. PMID 19348502, Free PMC Article
    3. Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa. Westman EL, et al. J Biol Chem, 2009 May 1. PMID 19282284, Free PMC Article
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biosynthesis of UDP-GlcNAc(3NAc)A by WbpD enzyme in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1
      Title: Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1.
    2. WbpD belongs to the hexapeptide acyltransferase (HexAT) superfamily of enzymes and involved in the fourth step of biosynthesis of UDP-d-Man(2NAc3NAc)A.
      Title: Evidence that WbpD is an N-acetyltransferase belonging to the hexapeptide acyltransferase superfamily and an important protein for O-antigen biosynthesis in Pseudomonas aeruginosa PAO1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables acetyltransferase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within O antigen biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within UDP-glucuronate biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within polysaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase
    NP_251846.1
    • Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      3540210..3540785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_251846.1 UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_251846.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      G3XD01
      Conserved Domains (1) summary
      cd03358
      Location:35 → 153
      LbH_WxcM_N_like; WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3XD01.1

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