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    amiB N-acetylmuramoyl-L-alanine amidase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878469, updated on 10-Oct-2024

    Summary

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    Gene symbol
    amiB
    Gene description
    N-acetylmuramoyl-L-alanine amidase
    Locus tag
    PA4947
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5551681..5553108, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene tRNA delta(2)-isopentenylpyrophosphate transferase Neighboring gene DNA mismatch repair protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cell wall amidase AmiB is essential for Pseudomonas aeruginosa cell division, drug resistance and viability. Yakhnina AA, et al. Mol Microbiol, 2015 Sep. PMID 26032134, Free PMC Article
    2. Production and purification of the bacterial autolysin N-acetylmuramoyl-L-alanine amidase B from Pseudomonas aeruginosa. Scheurwater EM, et al. Protein Expr Purif, 2007 Nov. PMID 17723308
    3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
    5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results revealed a key role for amidase activity in cytokinetic ring contraction. AmiB was found to be essential for viability and the successful completion of cell constriction.
      Title: The cell wall amidase AmiB is essential for Pseudomonas aeruginosa cell division, drug resistance and viability.
    2. The gene encoding N-acetylmuramoyl-L-alanine amidase B in Pseudomonas aeruginosa was cloned and over-expressed in Escherichia coli.
      Title: Production and purification of the bacterial autolysin N-acetylmuramoyl-L-alanine amidase B from Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    N-acetylmuramoyl-L-alanine amidase
    NP_253634.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5551681..5553108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253634.1 N-acetylmuramoyl-L-alanine amidase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253634.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2R3IUV6
      Conserved Domains (2) summary
      cd00118
      Location:424 → 467
      LysM; Lysin Motif is a small domain involved in binding peptidoglycan
      PRK10431
      Location:5 → 408
      PRK10431; N-acetylmuramoyl-l-alanine amidase II; Provisional
    Nucleotide Protein
    Heading Accession and Version

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