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    PA3346 two-component response regulator [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882513, updated on 24-Aug-2024

    Summary

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    Gene symbol
    PA3346
    Gene description
    two-component response regulator
    Locus tag
    PA3346
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (3757659..3759374, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene ATP-dependent DNA helicase RecQ Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene chemotaxis protein methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification, crystallization and preliminary X-ray crystallographic analysis of the receiver and stalk domains (PA3346RS) of the response regulator PA3346 from Pseudomonas aeruginosa PAO1. Wu PH, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Aug 1. PMID 21821900, Free PMC Article
    2. Identification of an HptB-mediated multi-step phosphorelay in Pseudomonas aeruginosa PAO1. Lin CT, et al. Res Microbiol, 2006 Mar. PMID 16182517
    3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
    5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. crystal of response regulator belonged to space group P4(1) or P4(3), with unit-cell parameters a = 82.38, c = 73.34 A. Preliminary analysis indicated the presence of a dimer of PA3346RS in the asymmetric unit, with a solvent content of 48.6%
      Title: Purification, crystallization and preliminary X-ray crystallographic analysis of the receiver and stalk domains (PA3346RS) of the response regulator PA3346 from Pseudomonas aeruginosa PAO1.
    2. We herein demonstrate that the hybrid sensor PA1611 carries out specific signal transduction, through HptB (PA3345), to the response regulator PA3346 in Pseudomonas aeruginosa PAO1.
      Title: Identification of an HptB-mediated multi-step phosphorelay in Pseudomonas aeruginosa PAO1.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    two-component response regulator
    NP_252036.1
    • 'Product name confidence: class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene)'

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      3757659..3759374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_252036.1 two-component response regulator [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_252036.1

      Status: PROVISIONAL

      Conserved Domains (2) summary
      COG2208
      Location:185 → 567
      RsbU; Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms, Transcription]
      cl19078
      Location:12 → 115
      REC; phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs)
    Nucleotide Protein
    Heading Accession and Version

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