Commd7 COMM domain containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Commd7provided by MGI
Official Full Name: COMM domain containing 7provided by MGI
Primary source: MGI:MGI:1914197
See related: Ensembl:ENSMUSG00000056941 AllianceGenome:MGI:1914197
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mU3; 2310010I22Rik
Summary: Predicted to enable NF-kappaB binding activity. Predicted to be involved in negative regulation of DNA-templated transcription; negative regulation of NF-kappaB transcription factor activity; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasmic vesicle. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and lung. Orthologous to human COMMD7 (COMM domain containing 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 7.4), CNS E18 (RPKM 6.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 75.73 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (153458850..153474712, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (153616930..153632795, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492298

AW060956 (e-PCR)
- UniSTS:164185

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NF-kappaB binding	IBA Inferred from Biological aspect of Ancestor more info
enables NF-kappaB binding	IEA Inferred from Electronic Annotation more info
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: COMM domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195390.1 → NP_001182319.1 COMM domain-containing protein 7 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AK078774, AK169037, AV146140, BX521840, BY295213

Consensus CDS

CCDS57187.1

UniProtKB/TrEMBL

A2AU52

Related

ENSMUSP00000105404.2, ENSMUST00000109782.2

Conserved Domains (1) summary

cl06336
Location:1 → 127

Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
NM_133850.2 → NP_598611.2 COMM domain-containing protein 7 isoform 1

See identical proteins and their annotated locations for NP_598611.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).

Source sequence(s)

AK078774, AV146140, BX521840, BY295213

Consensus CDS

CCDS16912.2

UniProtKB/Swiss-Prot

Q8BG94, Q99J75

UniProtKB/TrEMBL

Q56A13, Q8CF03

Related

ENSMUSP00000071752.4, ENSMUST00000071852.10

Conserved Domains (1) summary

cd04755
Location:19 → 198

Commd7; COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...