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    Gas5 growth arrest specific 5 [ Mus musculus (house mouse) ]

    Gene ID: 14455, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Gas5provided by MGI
    Official Full Name
    growth arrest specific 5provided by MGI
    Primary source
    MGI:MGI:95659
    See related
    Ensembl:ENSMUSG00000053332 AllianceGenome:MGI:95659
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gas-5; Snhg2; Mir5117
    Summary
    Acts upstream of or within several processes, including bone development; mRNA catabolic process; and osteoblast differentiation. Is expressed in several structures, including alimentary system; brain; metanephros; respiratory system; and sensory organ. Orthologous to human GAS5 (growth arrest specific 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 95.8), CNS E11.5 (RPKM 88.1) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gas5 in Genome Data Viewer
    Location:
    1 H2.1; 1 69.75 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (160862171..160866109)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161034601..161038539)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:162836371-162836672 Neighboring gene RING CCCH (C3H) domains 1 Neighboring gene serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 Neighboring gene predicted gene, 57574 Neighboring gene zinc finger and BTB domain containing 37 Neighboring gene STARR-positive B cell enhancer mm9_chr1:162964993-162965294 Neighboring gene predicted gene, 26224 Neighboring gene predicted gene, 22357 Neighboring gene predicted gene, 22489 Neighboring gene predicted gene, 23212 Neighboring gene small nucleolar RNA, C/D box 78 Neighboring gene small nucleolar RNA, C/D box 80 Neighboring gene small nucleolar RNA, C/D box 47 Neighboring gene predicted gene, 25789 Neighboring gene aspartyl-tRNA synthetase 2 (mitochondrial) Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163000837-163001115 Neighboring gene STARR-positive B cell enhancer ABC_E11097 Neighboring gene centromere protein L

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bulk and single-cell transcriptome profiling identify potential cellular targets of the long noncoding RNA Gas5 in renal fibrosis. Zhang X, et al. Biochim Biophys Acta Mol Basis Dis, 2024 Aug. PMID 38718848
    2. Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development. Coccia EM, et al. Mol Cell Biol, 1992 Aug. PMID 1630459, Free PMC Article
    3. Identification of a growth arrest specific (gas 5) gene by differential display as a candidate gene for determining susceptibility to hyperthermia-induced exencephaly in mice. Vacha SJ, et al. Dev Genet, 1997. PMID 9397537
    4. Expression of the snoRNA host gene gas5 in the hippocampus is upregulated by age and psychogenic stress and correlates with reduced novelty-induced behavior in C57BL/6 mice. Meier I, et al. Hippocampus, 2010 Sep. PMID 19739230
    5. Differential Expression of Glucocorticoid Receptor Noncoding RNA Repressor Gas5 in Autoimmune and Inflammatory Diseases. Mayama T, et al. Horm Metab Res, 2016 Aug. PMID 27214311

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gas5 regulates early-life stress-induced anxiety and spatial memory.
      Title: Gas5 regulates early-life stress-induced anxiety and spatial memory.
    2. Bulk and single-cell transcriptome profiling identify potential cellular targets of the long noncoding RNA Gas5 in renal fibrosis.
      Title: Bulk and single-cell transcriptome profiling identify potential cellular targets of the long noncoding RNA Gas5 in renal fibrosis.
    3. Exosomal lncRNA GAS5 promotes M1 macrophage polarization in allergic rhinitis via restraining mTORC1/ULK1/ATG13-mediated autophagy and subsequently activating NF-small ka, CyrillicB signaling.
      Title: Exosomal lncRNA GAS5 promotes M1 macrophage polarization in allergic rhinitis via restraining mTORC1/ULK1/ATG13-mediated autophagy and subsequently activating NF-кB signaling.
    4. LncRNA GAS5 suppresses TGF-beta1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRalpha/beta promoter.
      Title: LncRNA GAS5 suppresses TGF-β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoter.
    5. LncRNA GAS5 suppresses inflammatory responses by inhibiting HMGB1 release via miR-155-5p/SIRT1 axis in sepsis.
      Title: LncRNA GAS5 suppresses inflammatory responses by inhibiting HMGB1 release via miR-155-5p/SIRT1 axis in sepsis.
    6. LncRNA GAS5 Knockdown Mitigates Hepatic Lipid Accumulation via Regulating MiR-26a-5p/PDE4B to Activate cAMP/CREB Pathway.
      Title: LncRNA GAS5 Knockdown Mitigates Hepatic Lipid Accumulation via Regulating MiR-26a-5p/PDE4B to Activate cAMP/CREB Pathway.
    7. Gas5 inhibition promotes the axon regeneration in the adult mammalian nervous system.
      Title: Gas5 inhibition promotes the axon regeneration in the adult mammalian nervous system.
    8. Long noncoding RNA GAS5 attenuates cigarette smoke-induced airway remodeling by regulating miR-217-5p/PTEN axis.
      Title: Long noncoding RNA GAS5 attenuates cigarette smoke-induced airway remodeling by regulating miR-217-5p/PTEN axis.
    9. Long non-coding RNA GAS5 contributes to the progression of nonalcoholic fatty liver disease by targeting the microRNA-29a-3p/NOTCH2 axis.
      Title: Long non-coding RNA GAS5 contributes to the progression of nonalcoholic fatty liver disease by targeting the microRNA-29a-3p/NOTCH2 axis.
    10. LncRNA Gas5 regulates Fn1 deposition via Creb5 in renal fibrosis.
      Title: LncRNA Gas5 regulates Fn1 deposition via Creb5 in renal fibrosis.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6251

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within bone development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_153812.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163327
      Related
      ENSMUST00000310961.1

    2. NR_153813.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163327
      Related
      ENSMUST00000310910.1

    3. NR_153814.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163327
      Related
      ENSMUST00000247570.1

    4. NR_153815.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163327
      Related
      ENSMUST00000241235.2

    5. NR_166050.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163327
      Related
      ENSMUST00000310932.1

    6. NR_166051.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163327
      Related
      ENSMUST00000310895.1

    7. NR_166052.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163327
      Related
      ENSMUST00000244699.2

    8. NR_166055.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163327
      Related
      ENSMUST00000242491.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      160862171..160866109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_013525.1: Suppressed sequence

      Description
      NM_013525.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.

    2. NR_002840.2: Suppressed sequence

      Description
      NR_002840.2: This RefSeq was removed because it is primarily intronic sequence.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.