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    CSN9 Csn9p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851759, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CSN9
    Official Full Name
    Csn9p
    Primary source
    SGD:S000002586
    Locus tag
    YDR179C
    See related
    AllianceGenome:SGD:S000002586; FungiDB:YDR179C; VEuPathDB:YDR179C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in cellular response to pheromone; conjugation with cellular fusion; and protein deneddylation. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CSN9 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (818708..819196, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene E2 ubiquitin-conjugating protein UBC1 Neighboring gene succinate dehydrogenase membrane anchor subunit SDH4 Neighboring gene Nvj3p Neighboring gene cohesin-loading factor complex subunit SCC2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae as a Toolkit for COP9 Signalosome Research. Harshuk-Shabso D, et al. Biomolecules, 2021 Mar 25. PMID 33806190, Free PMC Article
    2. The COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae. Licursi V, et al. FEBS J, 2014 Jan. PMID 24164706
    3. The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes. Maytal-Kivity V, et al. Int J Biochem Cell Biol, 2003 May. PMID 12672462
    4. COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. Maytal-Kivity V, et al. EMBO Rep, 2002 Dec. PMID 12446563, Free PMC Article
    5. Conservation of the COP9/signalosome in budding yeast. Wee S, et al. BMC Genet, 2002 Aug 20. PMID 12186635, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deneddylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Csn9p
    NP_010464.1
    • Subunit of the Cop9 signalosome; Cop9 signalosome is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      818708..819196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180486.1 → NP_010464.1  TPA: Csn9p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010464.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSG1, Q03981
      UniProtKB/TrEMBL
      A6ZYD7, B3LGA4, C7GN18, C8Z592, G2WAS7, N1PAE9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03981.1

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