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    Pcdh8 protocadherin 8 [ Mus musculus (house mouse) ]

    Gene ID: 18530, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pcdh8provided by MGI
    Official Full Name
    protocadherin 8provided by MGI
    Primary source
    MGI:MGI:1306800
    See related
    Ensembl:ENSMUSG00000036422 AllianceGenome:MGI:1306800
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Papc; 1700080P15Rik
    Summary
    This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a type I transmembrane protein composed of an extracellular domain including 6 cadherin ectodomains, a single-pass transmembrane domain and a cytoplasmic tail. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons with the first large exon encoding the extracellular and transmembrane region. Although this gene product is capable of homophilic interaction, it appears to affect cell-cell adhesion indirectly by initiating signaling events that regulate classical cadherin-mediated adhesion. Based on studies on this protein and its orthologs, this protocadherin mainly functions in developing embryos and the central nervous system, but can also function as a tumor suppressor. Alternative splicing yielding isoforms with unique cytoplasmic tails has been reported. [provided by RefSeq, Sep 2009]
    Expression
    Biased expression in whole brain E14.5 (RPKM 19.8), CNS E18 (RPKM 18.6) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Pcdh8 in Genome Data Viewer
    Location:
    14 D3; 14 42.76 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (80004224..80008752, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (79766772..79771312, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37268 Neighboring gene STARR-seq mESC enhancer starr_37269 Neighboring gene microRNA 759 Neighboring gene predicted gene, 51404 Neighboring gene predicted gene 9748 Neighboring gene predicted gene 10845 Neighboring gene predicted gene 6999 Neighboring gene ubiquitin specific peptidase 15 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding  
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse  
    is_active_in Schaffer collateral - CA1 synapse  
    located_in dendrite  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in postsynaptic membrane  
    is_active_in postsynaptic membrane  
    located_in presynaptic membrane  
    is_active_in synapse  

    General protein information

    Preferred Names
    protocadherin-8
    Names
    arcadlin
    paraxial protocadherin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042726.4NP_001036191.1  protocadherin-8 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151973
      Consensus CDS
      CCDS79349.1
      UniProtKB/Swiss-Prot
      Q7TSK3
      Related
      ENSMUSP00000141417.2, ENSMUST00000195355.2
      Conserved Domains (2) summary
      cd11304
      Location:501605
      Cadherin_repeat; Cadherin tandem repeat domain
      cl09101
      Location:31109
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
    2. NM_021543.5NP_067518.2  protocadherin-8 isoform 1 precursor

      See identical proteins and their annotated locations for NP_067518.2

      Status: VALIDATED

      Source sequence(s)
      AC151973
      Consensus CDS
      CCDS27303.1
      UniProtKB/Swiss-Prot
      Q05BD0, Q7TSK3, Q8C824, Q9JKP3
      Related
      ENSMUSP00000045333.6, ENSMUST00000039568.11
      Conserved Domains (2) summary
      cd11304
      Location:501605
      Cadherin_repeat; Cadherin tandem repeat domain
      cl09101
      Location:31109
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      80004224..80008752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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