Cstl1 cystatin-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cstl1provided by MGI
Official Full Name: cystatin-like 1provided by MGI
Primary source: MGI:MGI:2652834
See related: Ensembl:ENSMUSG00000055177 AllianceGenome:MGI:2652834
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RCET1; RCET2; RCET3
Summary: Enables cysteine-type peptidase activity. Involved in signaling receptor ligand precursor processing. Predicted to be located in extracellular region. Is expressed in testis. Orthologous to human CSTL1 (cystatin like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 37.1) See more
Orthologs: human all
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Genomic context

Location:: 2 G3; 2 73.53 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (148592272..148597354)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (148750361..148755434)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Primarily expressed in mouse male reproductive tract; may play important roles in mouse spermatocyte and spermatid development.
Title: Cloning, characterization and identification of Rcet1-v1 and Rcet1-v2, two novel splice variants of mouse Rcet1 related to Cres subgroup of family 2 cystatins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in signaling receptor ligand precursor processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in signaling receptor ligand precursor processing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cystatin-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362207.1 → NP_001349136.1 cystatin-like 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL844519

Consensus CDS

CCDS89564.1

UniProtKB/TrEMBL

A0A2Q2AAE3

Related

ENSMUSP00000105580.2, ENSMUST00000109954.8

Conserved Domains (1) summary

cl09238
Location:28 → 86

CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.
NM_177655.4 → NP_808323.1 cystatin-like 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_808323.1

Status: VALIDATED

Source sequence(s)

AL844519

Consensus CDS

CCDS16844.1

UniProtKB/Swiss-Prot

Q3V2I7, Q64FK4, Q64FK5, Q80Y72

Related

ENSMUSP00000105581.4, ENSMUST00000109955.10

Conserved Domains (1) summary

smart00043
Location:32 → 138

CY; Cystatin-like domain