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    Med22 mediator complex subunit 22 [ Mus musculus (house mouse) ]

    Gene ID: 20933, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Med22provided by MGI
    Official Full Name
    mediator complex subunit 22provided by MGI
    Primary source
    MGI:MGI:98446
    See related
    Ensembl:ENSMUSG00000015776 AllianceGenome:MGI:98446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Surf5; Surf-5
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is expressed in embryo; tibialis anterior; and tongue. Orthologous to human MED22 (mediator complex subunit 22). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 19.6), ovary adult (RPKM 17.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Med22 in Genome Data Viewer
    Location:
    2 A3; 2 19.09 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26795279..26800654, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26905267..26910642, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Neighboring gene STARR-seq mESC enhancer starr_03995 Neighboring gene STARR-seq mESC enhancer starr_03996 Neighboring gene surfeit gene 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26758332-26758621 Neighboring gene predicted gene, 23969 Neighboring gene predicted gene, 22879 Neighboring gene ribosomal protein L7A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts. Angiolillo A, et al. Gene, 2002 Feb 6. PMID 11891058
    2. Inactivation of mediator complex protein 22 in podocytes results in intracellular vacuole formation, podocyte loss and premature death. Rodriguez PQ, et al. Sci Rep, 2020 Nov 18. PMID 33208756, Free PMC Article
    3. The mouse surfeit locus contains a cluster of six genes associated with four CpG-rich islands in 32 kilobases of genomic DNA. Huxley C, et al. Mol Cell Biol, 1990 Feb. PMID 2300057, Free PMC Article
    4. Primary structure and characterization of an androgen-stimulated autoantigen purified from mouse seminal-vesicle secretion. Yu LC, et al. Biochem J, 1993 Dec 15. PMID 8280054, Free PMC Article
    5. Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene. Garson K, et al. Genomics, 1995 Nov 20. PMID 8586415

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inactivation of mediator complex protein 22 in podocytes results in intracellular vacuole formation, podocyte loss and premature death.
      Title: Inactivation of mediator complex protein 22 in podocytes results in intracellular vacuole formation, podocyte loss and premature death.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 22
    Names
    surfeit gene 5
    surfeit locus protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033908.1 → NP_001029080.1  mediator of RNA polymerase II transcription subunit 22 isoform 2

      See identical proteins and their annotated locations for NP_001029080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses alternate splice sites in the coding region, compared to variant 1. The resulting isoform (2) is longer and has a unique C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AL773563, BG805496
      Consensus CDS
      CCDS15813.1
      UniProtKB/Swiss-Prot
      A2ALA2, Q3TTZ9, Q62276
      Related
      ENSMUSP00000015920.6, ENSMUST00000015920.12
      Conserved Domains (1) summary
      pfam06179
      Location:20 → 124
      Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

    2. NM_001378786.1 → NP_001365715.1  mediator of RNA polymerase II transcription subunit 22 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL773563
      Conserved Domains (1) summary
      pfam06179
      Location:20 → 160
      Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

    3. NM_001378787.1 → NP_001365716.1  mediator of RNA polymerase II transcription subunit 22 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL773563
      Conserved Domains (1) summary
      pfam06179
      Location:1 → 64
      Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

    4. NM_001378788.1 → NP_001365717.1  mediator of RNA polymerase II transcription subunit 22 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL773563
      Conserved Domains (1) summary
      pfam06179
      Location:20 → 97
      Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

    5. NM_011513.2 → NP_035643.1  mediator of RNA polymerase II transcription subunit 22 isoform 1

      See identical proteins and their annotated locations for NP_035643.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the shorter protein (isoform 1).
      Source sequence(s)
      AL773563
      Consensus CDS
      CCDS15814.1
      UniProtKB/Swiss-Prot
      Q62276
      Related
      ENSMUSP00000099963.4, ENSMUST00000102899.10
      Conserved Domains (1) summary
      pfam06179
      Location:20 → 124
      Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      26795279..26800654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62276.2 GenPept UniProtKB/Swiss-Prot:Q62276

    Gene LinkOut

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