Cnr2 cannabinoid receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnr2provided by MGI
Official Full Name: cannabinoid receptor 2provided by MGI
Primary source: MGI:MGI:104650
See related: Ensembl:ENSMUSG00000062585 AllianceGenome:MGI:104650
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CB2; CB-2; CB2-R
Summary: Predicted to enable cannabinoid receptor activity. Involved in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within leukocyte chemotaxis. Predicted to be located in dendrite; endoplasmic reticulum; and neuronal cell body. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Orthologous to human CNR2 (cannabinoid receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in spleen adult (RPKM 19.7), mammary gland adult (RPKM 6.0) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 68.01 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (135622500..135647530)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (135895189..135920219)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CB2 expression in mouse brain: from mapping to regulation in microglia under inflammatory conditions.
Title: CB2 expression in mouse brain: from mapping to regulation in microglia under inflammatory conditions.
Cannabinoid receptor 2 agonist AM1241 alleviates epileptic seizures and epilepsy-associated depression via inhibiting neuroinflammation in a pilocarpine-induced chronic epilepsy mouse model.
Title: Cannabinoid receptor 2 agonist AM1241 alleviates epileptic seizures and epilepsy-associated depression via inhibiting neuroinflammation in a pilocarpine-induced chronic epilepsy mouse model.
Activation of Cannabinoid Type 2 Receptor in Microglia Reduces Neuroinflammation through Inhibiting Aerobic Glycolysis to Relieve Hypertension.
Title: Activation of Cannabinoid Type 2 Receptor in Microglia Reduces Neuroinflammation through Inhibiting Aerobic Glycolysis to Relieve Hypertension.
Cannabinoid CB2 receptors and hypersensitivity to methamphetamine: Vulnerability to schizophrenia.
Title: Cannabinoid CB2 receptors and hypersensitivity to methamphetamine: Vulnerability to schizophrenia.
Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft-versus-host disease.
Title: Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft-versus-host disease.
Cannabinoid receptor 2 as a regulator of inflammation induced oleoylethanolamide in eosinophilic asthma.
Title: Cannabinoid receptor 2 as a regulator of inflammation induced oleoylethanolamide in eosinophilic asthma.
Role of the CB2 Cannabinoid Receptor in the Regulation of Food Intake: A Systematic Review.
Title: Role of the CB2 Cannabinoid Receptor in the Regulation of Food Intake: A Systematic Review.
The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement.
Title: The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement.
Cannabinoid receptor 2 alleviates sepsis-associated acute lung injury by modulating maturation of dendritic cells.
Title: Cannabinoid receptor 2 alleviates sepsis-associated acute lung injury by modulating maturation of dendritic cells.
Specific Activation of CB2R Ameliorates Psoriasis-Like Skin Lesions by Inhibiting Inflammation and Oxidative Stress.
Title: Specific Activation of CB2R Ameliorates Psoriasis-Like Skin Lesions by Inhibiting Inflammation and Oxidative Stress.

Submit: New GeneRIF Correction See all GeneRIFs (243)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cnr2 (e-PCR), detects polymorphism
- UniSTS:141364

UniSTS:495964 (e-PCR)
- UniSTS:495964

Cnr2 (e-PCR), detects polymorphism
- UniSTS:495964

X93168 (e-PCR)
- UniSTS:179091

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables cannabinoid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cannabinoid receptor activity	IEA Inferred from Electronic Annotation more info
enables cannabinoid receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cannabinoid signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leukocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of action potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mast cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cannabinoid receptor 2

Names: cannabinoid receptor 2 (macrophage); cannabinoid receptor 2 (spleen)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.