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    Zbtb5 zinc finger and BTB domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 230119, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zbtb5provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 5provided by MGI
    Primary source
    MGI:MGI:1924601
    See related
    Ensembl:ENSMUSG00000049657 AllianceGenome:MGI:1924601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0354; 5930421I10; 9430083K24Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; nervous system; and skin. Orthologous to human ZBTB5 (zinc finger and BTB domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.9), whole brain E14.5 (RPKM 8.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb5 in Genome Data Viewer
    Location:
    4 B1; 4 23.66 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (44991242..45012412, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (44991242..45012412, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8808 Neighboring gene STARR-positive B cell enhancer ABC_E2110 Neighboring gene predicted gene 12679 Neighboring gene STARR-positive B cell enhancer ABC_E6170 Neighboring gene glyoxylate reductase/hydroxypyruvate reductase Neighboring gene RIKEN cDNA 1700055D18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45025246-45025433 Neighboring gene STARR-positive B cell enhancer ABC_E71 Neighboring gene STARR-seq mESC enhancer starr_10090 Neighboring gene polymerase (RNA) I polypeptide E Neighboring gene F-box protein 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0354

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 5
    Names
    expressed in brain and neural tube
    transcription factor ZNF-POZ

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163283.1 → NP_001156755.1  zinc finger and BTB domain-containing protein 5

      See identical proteins and their annotated locations for NP_001156755.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      BC054551, BC057545, CN665638
      Consensus CDS
      CCDS18129.1
      UniProtKB/Swiss-Prot
      Q3TVR7, Q6GV09, Q7TQG0, Q8BIB5
      Related
      ENSMUSP00000136507.2, ENSMUST00000180217.2
      Conserved Domains (4) summary
      smart00225
      Location:25 → 119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:608 → 628
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:14 → 119
      BTB; BTB/POZ domain
      pfam13465
      Location:620 → 645
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001163284.1 → NP_001156756.1  zinc finger and BTB domain-containing protein 5

      See identical proteins and their annotated locations for NP_001156756.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      BC054551, BC057545
      Consensus CDS
      CCDS18129.1
      UniProtKB/Swiss-Prot
      Q3TVR7, Q6GV09, Q7TQG0, Q8BIB5
      Related
      ENSMUSP00000103447.3, ENSMUST00000107817.3
      Conserved Domains (4) summary
      smart00225
      Location:25 → 119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:608 → 628
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:14 → 119
      BTB; BTB/POZ domain
      pfam13465
      Location:620 → 645
      zf-H2C2_2; Zinc-finger double domain

    3. NM_173399.3 → NP_775575.2  zinc finger and BTB domain-containing protein 5

      See identical proteins and their annotated locations for NP_775575.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      BC054551, BC057545
      Consensus CDS
      CCDS18129.1
      UniProtKB/Swiss-Prot
      Q3TVR7, Q6GV09, Q7TQG0, Q8BIB5
      Related
      ENSMUSP00000059919.9, ENSMUST00000055028.9
      Conserved Domains (4) summary
      smart00225
      Location:25 → 119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:608 → 628
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:14 → 119
      BTB; BTB/POZ domain
      pfam13465
      Location:620 → 645
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      44991242..45012412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQG0.1 GenPept UniProtKB/Swiss-Prot:Q7TQG0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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