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    Lrrc8b leucine rich repeat containing 8 family, member B [ Mus musculus (house mouse) ]

    Gene ID: 433926, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc8bprovided by MGI
    Official Full Name
    leucine rich repeat containing 8 family, member Bprovided by MGI
    Primary source
    MGI:MGI:2141353
    See related
    Ensembl:ENSMUSG00000070639 AllianceGenome:MGI:2141353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ta-lrrp; mKIAA0231; 2210408K08Rik
    Summary
    Predicted to enable volume-sensitive anion channel activity. Predicted to be involved in several processes, including aspartate transmembrane transport; cyclic-GMP-AMP transmembrane import across plasma membrane; and monoatomic anion transmembrane transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human LRRC8B (leucine rich repeat containing 8 VRAC subunit B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 142.7), adrenal adult (RPKM 13.7) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc8b in Genome Data Viewer
    Location:
    5 E5; 5 50.68 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105563072..105637945)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105415206..105490079)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26519 Neighboring gene STARR-positive B cell enhancer ABC_E8067 Neighboring gene RIKEN cDNA 4930542N06 gene Neighboring gene predicted gene, 32051 Neighboring gene STARR-seq mESC enhancer starr_13851 Neighboring gene STARR-seq mESC enhancer starr_13852 Neighboring gene STARR-positive B cell enhancer ABC_E6355 Neighboring gene predicted gene, 42141 Neighboring gene predicted gene, 42144

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy. López-Cayuqueo KI, et al. J Am Soc Nephrol, 2022 Aug. PMID 35777784, Free PMC Article
    2. Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Zhou C, et al. Immunity, 2020 May 19. PMID 32277911
    3. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0231

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables volume-sensitive anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to volume-sensitive anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to volume-sensitive anion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in aspartate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic anion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic anion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic anion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of monoatomic ion channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of monoatomic ion channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    volume-regulated anion channel subunit LRRC8B
    Names
    T-cell activation leucine repeat-rich protein
    leucine-rich repeat-containing protein 8B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033550.4 → NP_001028722.1  volume-regulated anion channel subunit LRRC8B

      See identical proteins and their annotated locations for NP_001028722.1

      Status: VALIDATED

      Source sequence(s)
      AC113980, AC138265
      Consensus CDS
      CCDS39193.1
      UniProtKB/Swiss-Prot
      B2RSI6, Q5DU41
      Related
      ENSMUSP00000108327.2, ENSMUST00000112707.3
      Conserved Domains (4) summary
      PLN00113
      Location:428 → 692
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:578 → 794
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:465 → 488
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 334
      Pannexin_like; Pannexin-like TM region of LRRC8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      105563072..105637945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254652.1 → XP_030110512.1  volume-regulated anion channel subunit LRRC8B isoform X1

      UniProtKB/Swiss-Prot
      B2RSI6, Q5DU41
      Conserved Domains (4) summary
      PLN00113
      Location:428 → 692
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:578 → 794
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:465 → 488
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 334
      Pannexin_like; Pannexin-like TM region of LRRC8

    2. XM_030254653.1 → XP_030110513.1  volume-regulated anion channel subunit LRRC8B isoform X1

      UniProtKB/Swiss-Prot
      B2RSI6, Q5DU41
      Conserved Domains (4) summary
      PLN00113
      Location:428 → 692
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:578 → 794
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:465 → 488
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 334
      Pannexin_like; Pannexin-like TM region of LRRC8

    3. XM_030254651.2 → XP_030110511.1  volume-regulated anion channel subunit LRRC8B isoform X1

      UniProtKB/Swiss-Prot
      B2RSI6, Q5DU41
      Conserved Domains (4) summary
      PLN00113
      Location:428 → 692
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:578 → 794
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:465 → 488
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 334
      Pannexin_like; Pannexin-like TM region of LRRC8

    4. XM_011249508.3 → XP_011247810.1  volume-regulated anion channel subunit LRRC8B isoform X1

      See identical proteins and their annotated locations for XP_011247810.1

      UniProtKB/Swiss-Prot
      B2RSI6, Q5DU41
      Conserved Domains (4) summary
      PLN00113
      Location:428 → 692
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:578 → 794
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:465 → 488
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 334
      Pannexin_like; Pannexin-like TM region of LRRC8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DU41.3 GenPept UniProtKB/Swiss-Prot:Q5DU41

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