P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: P2rx2provided by MGI
Official Full Name: purinergic receptor P2X, ligand-gated ion channel, 2provided by MGI
Primary source: MGI:MGI:2665170
See related: Ensembl:ENSMUSG00000029503 AllianceGenome:MGI:2665170
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P2x2; P2X2a
Summary: Enables extracellularly ATP-gated monoatomic cation channel activity. Involved in sensory perception of sound. Acts upstream of or within several processes, including neuromuscular synaptic transmission; skeletal muscle fiber development; and smooth muscle contraction. Located in plasma membrane. Is active in neuronal dense core vesicle. Is expressed in facial ganglion; heart; medulla oblongata basal plate mantle layer; and vagus ganglion. Used to study autosomal dominant nonsyndromic deafness 41. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 29.2), genital fat pad adult (RPKM 19.6) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 53.49 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (110487678..110491186, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (110339812..110343320, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P2X2 receptors in pyramidal neurons are critical for regulating vulnerability to chronic stress.
Title: P2X2 receptors in pyramidal neurons are critical for regulating vulnerability to chronic stress.
Generation and characterization of a P2rx2 V60L mouse model for DFNA41.
Title: Generation and characterization of a P2rx2 V60L mouse model for DFNA41.
BAC transgenic mice to study the expression of P2X2 and P2Y1 receptors.
Title: BAC transgenic mice to study the expression of P2X2 and P2Y(1) receptors.
Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge.
Title: Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge.
P2RX2 and P2RX4 receptors mediate cation absorption in transitional cells and supporting cells of the utricular macula.
Title: P2RX2 and P2RX4 receptors mediate cation absorption in transitional cells and supporting cells of the utricular macula.
P2X2 receptors are mainly localized in the supporting cells of the vestibular inner ear, and loss of P2X2 receptors causes mild vestibular dysfunction.
Title: P2X(2) Receptor Deficiency in Mouse Vestibular End Organs Attenuates Vestibular Function.
These results indicate that the P2X2aR is a novel target for Cdk5-mediated phosphorylation, which might play important physiological roles including pain signaling.
Title: Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372.
results indicate that the lateral border of the P2X2 terminal field, demarcates a faithful "transition zone," where AO responses transition from gustatory to mechanosensory
Title: P2X2 Receptor Terminal Field Demarcates a "Transition Zone" for Gustatory and Mechanosensory Processing in the Mouse Nucleus Tractus Solitarius.
may be involved in skeletal pain due to high bone turnover
Title: Acid-sensing ion channel 3 or P2X2/3 is involved in the pain-like behavior under a high bone turnover state in ovariectomized mice.
Obesity promotes down regulation of P2rx2 receptor expression in enteric neurons innervating the ileum.
Title: Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice (ob/ob).

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables cadmium ion binding	ISO Inferred from Sequence Orthology more info
enables cobalt ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables extracellularly ATP-gated monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly ATP-gated monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables mercury ion binding	ISO Inferred from Sequence Orthology more info
enables nickel cation binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info
enables purinergic nucleotide receptor activity	ISO Inferred from Sequence Orthology more info
enables suramin binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral response to pain	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of hypoxic conditions in blood by carotid body chemoreceptor signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peristalsis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to ATP	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to ATP	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to carbohydrate	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of taste	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within urinary bladder smooth muscle contraction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within urinary bladder smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in neuronal dense core vesicle	EXP Inferred from Experiment more info	PubMed
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: P2X purinoceptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164833.1 → NP_001158305.1 P2X purinoceptor 2 isoform b

See identical proteins and their annotated locations for NP_001158305.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 3' coding region compared to variant 1. The encoded protein (isoform b) is shorter than isoform a.

Source sequence(s)

AB094664, BY236715

Consensus CDS

CCDS51608.1

UniProtKB/Swiss-Prot

Q8K3P1

Related

ENSMUSP00000108097.4, ENSMUST00000112478.8

Conserved Domains (1) summary

TIGR00863
Location:14 → 380

P2X; cation transporter protein
NM_001164834.1 → NP_001158306.1 P2X purinoceptor 2 isoform c

See identical proteins and their annotated locations for NP_001158306.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame segment in the 3' coding region compared to variant 1. The encoded protein (isoform e) is shorter than isoform a.

Source sequence(s)

AB094663, BY236715

Consensus CDS

CCDS80362.1

UniProtKB/Swiss-Prot

Q8K3P1

Related

ENSMUSP00000143554.2, ENSMUST00000200037.5

Conserved Domains (1) summary

TIGR00863
Location:14 → 380

P2X; cation transporter protein
NM_001310700.1 → NP_001297629.1 P2X purinoceptor 2 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (d) is longer than isoform 1.

Source sequence(s)

AK141196, AK158334, BY236715, BY595018

Consensus CDS

CCDS80363.1

UniProtKB/Swiss-Prot

Q8K3P1

Related

ENSMUSP00000054233.11, ENSMUST00000058016.16

Conserved Domains (2) summary

TIGR00863
Location:14 → 392

P2X; cation transporter protein

pfam06409
Location:399 → 458

NPIP; Nuclear pore complex interacting protein (NPIP)
NM_001310701.1 → NP_001297630.1 P2X purinoceptor 2 isoform e

See identical proteins and their annotated locations for NP_001297630.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (e) has a shorter N-terminus than isoform a.

Source sequence(s)

AC123699

Consensus CDS

CCDS80361.1

UniProtKB/Swiss-Prot

Q8K3P1

Related

ENSMUSP00000142567.2, ENSMUST00000200214.2

Conserved Domains (1) summary

cl02993
Location:1 → 293

P2X_receptor; ATP P2X receptor
NM_153400.4 → NP_700449.2 P2X purinoceptor 2 isoform a

See identical proteins and their annotated locations for NP_700449.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform a.

Source sequence(s)

AB094663, AB094664, AK141196, BY236715

Consensus CDS

CCDS51607.1

UniProtKB/Swiss-Prot

Q3KP15, Q3TYV0, Q812E6, Q812E7, Q8K3P1

Related

ENSMUSP00000143047.2, ENSMUST00000195985.5

Conserved Domains (2) summary

TIGR00863
Location:14 → 380

P2X; cation transporter protein

pfam06409
Location:387 → 446

NPIP; Nuclear pore complex interacting protein (NPIP)