Chlsn cholesin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chlsnprovided by MGI
Official Full Name: cholesinprovided by MGI
Primary source: MGI:MGI:1920462
See related: Ensembl:ENSMUSG00000053553 AllianceGenome:MGI:1920462
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C7orf50; 3110082I17Rik
Summary: Predicted to enable hormone activity. Predicted to be involved in negative regulation of cholesterol biosynthetic process and signal transduction. Predicted to be located in extracellular space. Is expressed in several structures, including adrenal gland; brain; genitourinary system; gut gland; and trachea. Orthologous to human C7orf50 (chromosome 7 open reading frame 50). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 8.4), limb E14.5 (RPKM 5.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 78.45 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (139345494..139446291, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (139359739..139460534, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A gut-derived hormone regulates cholesterol metabolism.
Title: A gut-derived hormone regulates cholesterol metabolism.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

D5Dcr17 (e-PCR), detects polymorphism
- UniSTS:507719

NoName (e-PCR)
- UniSTS:235348

AW411904 (e-PCR)
- UniSTS:179303

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cholesin

Names: uncharacterized protein C7orf50 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.