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    Isoc2b isochorismatase domain containing 2b [ Mus musculus (house mouse) ]

    Gene ID: 67441, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Isoc2bprovided by MGI
    Official Full Name
    isochorismatase domain containing 2bprovided by MGI
    Primary source
    MGI:MGI:1914691
    See related
    Ensembl:ENSMUSG00000052605 AllianceGenome:MGI:1914691
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Isoc2; 0610042E07Rik
    Summary
    Predicted to be involved in protein destabilization. Located in mitochondrion. Orthologous to human ISOC2 (isochorismatase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 18.1), kidney adult (RPKM 14.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Isoc2b in Genome Data Viewer
    Location:
    7 A1; 7 2.8 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4847958..4869178, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4844959..4866179, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E441 Neighboring gene ubiquitin-conjugating enzyme E2S Neighboring gene STARR-seq mESC enhancer starr_17941 Neighboring gene shisa family member 7 Neighboring gene predicted gene, 36127 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4817662-4817771 Neighboring gene predicted gene, 53350 Neighboring gene STARR-positive B cell enhancer ABC_E2220 Neighboring gene isochorismatase domain containing 2a Neighboring gene STARR-seq mESC enhancer starr_17947 Neighboring gene predicted gene, 36210

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    isochorismatase domain-containing protein 2B
    Names
    isochorismatase domain-containing protein 2B, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026158.2 → NP_080434.1  isochorismatase domain-containing protein 2B

      See identical proteins and their annotated locations for NP_080434.1

      Status: PROVISIONAL

      Source sequence(s)
      AK002905
      Consensus CDS
      CCDS20748.1
      UniProtKB/Swiss-Prot
      Q80V19, Q9DCC7
      Related
      ENSMUSP00000066859.6, ENSMUST00000064547.13
      Conserved Domains (1) summary
      cl00220
      Location:18 → 170
      cysteine_hydrolases; Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4847958..4869178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540328.4 → XP_006540391.1  isochorismatase domain-containing protein 2B isoform X1

      Conserved Domains (1) summary
      cl00220
      Location:20 → 172
      cysteine_hydrolases; Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCC7.1 GenPept UniProtKB/Swiss-Prot:Q9DCC7

    Gene LinkOut

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