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    Dhx34 DExH-box helicase 34 [ Mus musculus (house mouse) ]

    Gene ID: 71723, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhx34provided by MGI
    Official Full Name
    DExH-box helicase 34provided by MGI
    Primary source
    MGI:MGI:1918973
    See related
    Ensembl:ENSMUSG00000006019 AllianceGenome:MGI:1918973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ddx34; mKIAA0134; 1200013B07Rik; 1810012L18Rik
    Summary
    Predicted to enable ATP hydrolysis activity; RNA binding activity; and helicase activity. Predicted to be involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and positive regulation of phosphorylation. Is expressed in pancreas and pancreas tip epithelium. Orthologous to human DHX34 (DExH-box helicase 34). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 14.7), spleen adult (RPKM 13.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dhx34 in Genome Data Viewer
    Location:
    7 8.76 cM; 7 A2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (15931145..15956005, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16197220..16222078, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 (sodium/calcium exchanger), member 2 Neighboring gene Meis homeobox 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:16786573-16786682 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:16792577-16792686 Neighboring gene STARR-positive B cell enhancer ABC_E1334 Neighboring gene STARR-seq mESC enhancer starr_18126 Neighboring gene STARR-positive B cell enhancer ABC_E9684 Neighboring gene predicted gene, 26473 Neighboring gene complement component 5a receptor 2 Neighboring gene complement component 5a receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    3. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent RNA helicase DHX34
    Names
    DEAH (Asp-Glu-Ala-His) box polypeptide 34
    DEAH box protein 34
    NP_001272860.1
    NP_001272861.1
    NP_082159.3
    XP_006540432.1
    XP_006540434.1
    XP_017167800.1
    XP_030098852.1
    XP_030098853.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285931.1 → NP_001272860.1  probable ATP-dependent RNA helicase DHX34

      See identical proteins and their annotated locations for NP_001272860.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AK004733, BC058370, BC080856, CB525602
      Consensus CDS
      CCDS39783.1
      UniProtKB/TrEMBL
      A0A0R4J217, Q66JM5
      Related
      ENSMUSP00000113393.2, ENSMUST00000119102.8
      Conserved Domains (2) summary
      COG1643
      Location:153 → 688
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam07717
      Location:800 → 911
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    2. NM_001285932.1 → NP_001272861.1  probable ATP-dependent RNA helicase DHX34

      See identical proteins and their annotated locations for NP_001272861.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK004733, BC080856, CB525602
      Consensus CDS
      CCDS39783.1
      UniProtKB/TrEMBL
      A0A0R4J217, Q66JM5
      Related
      ENSMUSP00000092410.3, ENSMUST00000094816.3
      Conserved Domains (2) summary
      COG1643
      Location:153 → 688
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam07717
      Location:800 → 911
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    3. NM_027883.3 → NP_082159.3  probable ATP-dependent RNA helicase DHX34

      See identical proteins and their annotated locations for NP_082159.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK004733
      Consensus CDS
      CCDS39783.1
      UniProtKB/TrEMBL
      A0A0R4J217, Q66JM5
      Related
      ENSMUSP00000126915.2, ENSMUST00000163968.8
      Conserved Domains (2) summary
      COG1643
      Location:153 → 688
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam07717
      Location:800 → 911
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      15931145..15956005 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242992.2 → XP_030098852.1  probable ATP-dependent RNA helicase DHX34 isoform X2

      Conserved Domains (3) summary
      smart00847
      Location:27 → 73
      HA2; Helicase associated domain (HA2) Add an annotation
      TIGR01967
      Location:31 → 124
      DEAH_box_HrpA; RNA helicase HrpA
      pfam07717
      Location:226 → 336
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    2. XM_017312311.2 → XP_017167800.1  probable ATP-dependent RNA helicase DHX34 isoform X1

      UniProtKB/TrEMBL
      A0A0R4J217, Q66JM5
      Conserved Domains (2) summary
      COG1643
      Location:153 → 688
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam07717
      Location:800 → 911
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    3. XM_006540369.4 → XP_006540432.1  probable ATP-dependent RNA helicase DHX34 isoform X1

      See identical proteins and their annotated locations for XP_006540432.1

      UniProtKB/TrEMBL
      A0A0R4J217, Q66JM5
      Conserved Domains (2) summary
      COG1643
      Location:153 → 688
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam07717
      Location:800 → 911
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    4. XM_030242993.1 → XP_030098853.1  probable ATP-dependent RNA helicase DHX34 isoform X4

      Conserved Domains (2) summary
      smart00847
      Location:1 → 54
      HA2; Helicase associated domain (HA2) Add an annotation
      pfam07717
      Location:207 → 317
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    5. XM_006540371.5 → XP_006540434.1  probable ATP-dependent RNA helicase DHX34 isoform X3

      Conserved Domains (3) summary
      smart00847
      Location:17 → 64
      HA2; Helicase associated domain (HA2) Add an annotation
      TIGR01967
      Location:22 → 115
      DEAH_box_HrpA; RNA helicase HrpA
      pfam07717
      Location:217 → 327
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RNA

    1. XR_391100.5 RNA Sequence

    2. XR_003946563.1 RNA Sequence

    3. XR_003946564.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBV3.2 GenPept UniProtKB/Swiss-Prot:Q9DBV3

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