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    Psg20 pregnancy-specific beta-1-glycoprotein 20 [ Mus musculus (house mouse) ]

    Gene ID: 434540, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psg20provided by MGI
    Official Full Name
    pregnancy-specific beta-1-glycoprotein 20provided by MGI
    Primary source
    MGI:MGI:1891352
    See related
    Ensembl:ENSMUSG00000063305 AllianceGenome:MGI:1891352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cea7; EG434540
    Summary
    Predicted to enable protein heterodimerization activity. Predicted to be involved in T cell activation and immune response. Predicted to be located in several cellular components, including apical plasma membrane; cell surface; and extracellular space. Predicted to be active in external side of plasma membrane. Orthologous to several human genes including CEACAM4 (CEA cell adhesion molecule 4); CEACAM7 (CEA cell adhesion molecule 7); and CEACAM8 (CEA cell adhesion molecule 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 1.5) and testis adult (RPKM 0.1) See more
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    Genomic context

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    See Psg20 in Genome Data Viewer
    Location:
    7 A3; 7 9.23 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18407910..18420218, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (18673985..18686277, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RNA (guanine-9-) methyltransferase domain containing 2 pseudogene Neighboring gene pregnancy-specific beta-1-glycoprotein 21 Neighboring gene STARR-seq mESC enhancer starr_18172 Neighboring gene STARR-seq mESC enhancer starr_18173 Neighboring gene pregnancy-specific beta-1-glycoprotein 22 Neighboring gene predicted gene, 24464

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Tunster SJ, et al. Dev Biol, 2016 Jan 1. PMID 26476147, Free PMC Article
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pregnancy-specific glycoprotein 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054058.1 → NP_473399.1  pregnancy-specific glycoprotein 20 precursor

      Status: VALIDATED

      Source sequence(s)
      AC165084
      Conserved Domains (3) summary
      cd05774
      Location:156 → 260
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00408
      Location:400 → 461
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:395 → 472
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      18407910..18420218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242757.2 → XP_030098617.1  pregnancy-specific glycoprotein 20 isoform X1

      UniProtKB/TrEMBL
      E9Q6J6
      Related
      ENSMUSP00000104122.2, ENSMUST00000108482.8
      Conserved Domains (2) summary
      smart00408
      Location:397 → 458
      IGc2; Immunoglobulin C-2 Type
      cd05774
      Location:156 → 260
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    Nucleotide Protein Strain
    Heading Accession and Version

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