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    Zfp780b zinc finger protein 780B [ Mus musculus (house mouse) ]

    Gene ID: 338354, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp780bprovided by MGI
    Official Full Name
    zinc finger protein 780Bprovided by MGI
    Primary source
    MGI:MGI:2444764
    See related
    Ensembl:ENSMUSG00000063047 AllianceGenome:MGI:2444764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230208L21Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human ZNF780B (zinc finger protein 780B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 2.6), CNS E18 (RPKM 1.5) and 23 other tissues See more
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    Genomic context

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    See Zfp780b in Genome Data Viewer
    Location:
    7 A3; 7 15.97 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27658560..27678768, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27959135..27979336, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53355 Neighboring gene Josephin domain containing 1, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2231 Neighboring gene vomeronasal 1 receptor, pseudogene 87 Neighboring gene zinc finger protein 850

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106695

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 780B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081021.2 → NP_001074490.1  zinc finger protein 780B isoform 1

      See identical proteins and their annotated locations for NP_001074490.1

      Status: VALIDATED

      Source sequence(s)
      AC139063
      Consensus CDS
      CCDS39853.1
      UniProtKB/TrEMBL
      E9Q2S6
      Related
      ENSMUSP00000146224.2, ENSMUST00000206685.2
      Conserved Domains (3) summary
      smart00349
      Location:14 → 75
      KRAB; krueppel associated box
      COG5048
      Location:197 → 605
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:425 → 445
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001419345.1 → NP_001406274.1  zinc finger protein 780B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC139063
      UniProtKB/TrEMBL
      E9Q2S6
      Related
      ENSMUSP00000080324.8, ENSMUST00000081618.8

    3. NM_001419346.1 → NP_001406275.1  zinc finger protein 780B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC139063
      UniProtKB/TrEMBL
      E9Q2S6

    4. NM_001419347.1 → NP_001406276.1  zinc finger protein 780B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC139063
      UniProtKB/TrEMBL
      E9Q2S6

    5. NM_001419348.1 → NP_001406277.1  zinc finger protein 780B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC139063
      UniProtKB/TrEMBL
      E9Q2S6

    6. NM_001419349.1 → NP_001406278.1  zinc finger protein 780B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC139063

    7. NM_001419350.1 → NP_001406279.1  zinc finger protein 780B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC139063
      UniProtKB/TrEMBL
      Q52KI6
      Related
      ENSMUSP00000145799.2, ENSMUST00000205874.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      27658560..27678768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242709.2 → XP_030098569.1  zinc finger protein 780B isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:126 → 534
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:354 → 374
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_030242706.2 → XP_030098566.1  zinc finger protein 780B isoform X1

      UniProtKB/TrEMBL
      E9Q2S6
      Conserved Domains (3) summary
      smart00349
      Location:14 → 75
      KRAB; krueppel associated box
      COG5048
      Location:197 → 605
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:425 → 445
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_030242702.2 → XP_030098562.1  zinc finger protein 780B isoform X1

      UniProtKB/TrEMBL
      E9Q2S6
      Conserved Domains (3) summary
      smart00349
      Location:14 → 75
      KRAB; krueppel associated box
      COG5048
      Location:197 → 605
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:425 → 445
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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