PLA2G2F phospholipase A2 group IIF [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLA2G2Fprovided by HGNC
Official Full Name: phospholipase A2 group IIFprovided by HGNC
Primary source: HGNC:HGNC:30040
See related: Ensembl:ENSG00000158786 MIM:616793; AllianceGenome:HGNC:30040
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GIIFsPLA2; sPLA2-IIF
Summary: Enables calcium-dependent phospholipase A2 activity. Involved in glycerophospholipid metabolic process. Predicted to be located in cytosol and extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in skin (RPKM 4.4), urinary bladder (RPKM 2.2) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (20139323..20150381)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (19962968..19974035)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (20465816..20476874)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

two of these isoforms, sPLA2 IIA and sPLA2 IIF, localize to the upper stratum granulosum and increase in response to experimental barrier perturbation.
Title: sPLA2 and the epidermal barrier.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of phospholipase A2, group IIF (PLA2G2F) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion	PubMed
	env	HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-independent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	NAS Non-traceable Author Statement more info	PubMed
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine acyl-chain remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine acyl-chain remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylglycerol acyl-chain remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylserine acyl-chain remodeling	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: group IIF secretory phospholipase A2

Names: GIIF sPLA2; phosphatidylcholine 2-acylhydrolase 2F

NP_001347798.1

EC 3.1.1.4

NP_073730.3

EC 3.1.1.4

XP_011540257.1

EC 3.1.1.4

XP_011540258.1

EC 3.1.1.4

XP_054194190.1

EC 3.1.1.4

XP_054194191.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360869.2 → NP_001347798.1 group IIF secretory phospholipase A2 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1a) reflects the use of an in-frame downstream start codon for translation, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus with a predicted signal peptide, compared to isoform 1. With the available conservation data, it is not clear which start codon is most likely used.

Source sequence(s)

AF306566, AK093645, AL158172, BM987713, BX647458, Z98257

UniProtKB/Swiss-Prot

Q5R385, Q8N217, Q9BZM2, Q9H506

Conserved Domains (1) summary

cd00125
Location:21 → 138

PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
NM_022819.4 → NP_073730.3 group IIF secretory phospholipase A2 isoform 1

See identical proteins and their annotated locations for NP_073730.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes a longer protein (isoform 1), which lacks a signal peptide. With the available conservation data, it is not clear which start codon is most likely used.

Source sequence(s)

AF306566, AK093645, AL158172, BM987713, BX647458, Z98257

Consensus CDS

CCDS204.2

UniProtKB/Swiss-Prot

Q9BZM2

Related

ENSP00000364243.4, ENST00000375102.4

Conserved Domains (1) summary

cd00125
Location:64 → 181

PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

20139323..20150381

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011541955.2 → XP_011540257.1 group IIF secretory phospholipase A2 isoform X1

Conserved Domains (1) summary

cd00125
Location:64 → 142

PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
XM_011541956.2 → XP_011540258.1 group IIF secretory phospholipase A2 isoform X2

See identical proteins and their annotated locations for XP_011540258.1

UniProtKB/Swiss-Prot

Q9BZM2

Conserved Domains (1) summary

cd00125
Location:64 → 181

PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...