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    Neu2 neuraminidase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29204, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Neu2provided by RGD
    Official Full Name
    neuraminidase 2provided by RGD
    Primary source
    RGD:3164
    See related
    AllianceGenome:RGD:3164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables exo-alpha-sialidase activity. Involved in positive regulation of myoblast differentiation; positive regulation of myotube differentiation; and response to ethanol. Predicted to be located in cytosol. Predicted to be part of catalytic complex. Predicted to be active in lysosome and membrane. Orthologous to human NEU2 (neuraminidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 52.7), Brain (RPKM 11.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Neu2 in Genome Data Viewer
    Location:
    9q35
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (95666338..95715209)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (88218494..88267356)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (94702095..94724903)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene GRB10 interacting GYF protein 2 Neighboring gene uncharacterized LOC134480606 Neighboring gene secondary ossification center associated regulator of chondrocyte maturation Neighboring gene neuronal guanine nucleotide exchange factor Neighboring gene uncharacterized LOC120094737 Neighboring gene inositol polyphosphate-5-phosphatase D Neighboring gene uncharacterized LOC134480608

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The enzymatic activity of sialidase Neu2 is inversely regulated during in vitro myoblast hypertrophy and atrophy. Fanzani A, et al. Biochem Biophys Res Commun, 2008 May 30. PMID 18384747
    2. Chronic ethanol consumption upregulates the cytosolic and plasma membrane sialidase genes, but down regulates lysosomal membrane sialidase gene in rat liver. Garige M, et al. Metabolism, 2006 Jun. PMID 16713441
    3. An investigation of the activity of recombinant rat skeletal muscle cytosolic sialidase. Albouz-Abo S, et al. FEBS Lett, 2005 Feb 14. PMID 15710387
    4. Overexpression of cytosolic sialidase Neu2 induces myoblast differentiation in C2C12 cells. Fanzani A, et al. FEBS Lett, 2003 Jul 17. PMID 12860410
    5. [Immunohistochemical localization of cytosolic sialidase in the epithelium of rat cornea and conjunctiva]. Uehara F, et al. Nippon Ganka Gakkai Zasshi, 1997 Sep. PMID 9311229

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonstrates that Neu2 enzyme degradation occurs in atrophic myotubes via macroautophagy and independently of proteasome activation.
      Title: The cytosolic sialidase Neu2 is degraded by autophagy during myoblast atrophy.
    2. Neu2 enzymatic activity is causally linked to proper muscle differentiation and growth.
      Title: The enzymatic activity of sialidase Neu2 is inversely regulated during in vitro myoblast hypertrophy and atrophy.
    3. role during in vitro myoblast differentiation
      Title: Overexpression of cytosolic sialidase Neu2 induces myoblast differentiation in C2C12 cells.
    4. enzyme activity and substrate specificity
      Title: An investigation of the activity of recombinant rat skeletal muscle cytosolic sialidase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108717

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables exo-alpha-sialidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exo-alpha-sialidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables exo-alpha-sialidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exo-alpha-sialidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables exo-alpha-sialidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ganglioside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ganglioside catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ganglioside catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ganglioside catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycoprotein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycoprotein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligosaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of myoblast differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of myotube differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of catalytic complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sialidase-2
    Names
    N-acetyl-alpha-neuraminidase 2
    cytosolic sialidase
    NP_058826.2
    XP_006245423.1
    XP_006245424.1
    XP_017451791.1
    XP_038939036.1
    XP_038939037.1
    XP_038939038.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017130.2 → NP_058826.2  sialidase-2

      See identical proteins and their annotated locations for NP_058826.2

      Status: VALIDATED

      Source sequence(s)
      BC091154, JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JWN5, Q5BK97
      Conserved Domains (1) summary
      cd15482
      Location:10 → 367
      Sialidase_non-viral; Non-viral sialidases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      95666338..95715209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083110.2 → XP_038939038.1  sialidase-2 isoform X1

      UniProtKB/TrEMBL
      A6JWN5, Q5BK97
      Conserved Domains (1) summary
      cd15482
      Location:10 → 367
      Sialidase_non-viral; Non-viral sialidases

    2. XM_039083108.2 → XP_038939036.1  sialidase-2 isoform X1

      UniProtKB/TrEMBL
      A6JWN5, Q5BK97
      Conserved Domains (1) summary
      cd15482
      Location:10 → 367
      Sialidase_non-viral; Non-viral sialidases

    3. XM_039083109.2 → XP_038939037.1  sialidase-2 isoform X1

      UniProtKB/TrEMBL
      A6JWN5, Q5BK97
      Conserved Domains (1) summary
      cd15482
      Location:10 → 367
      Sialidase_non-viral; Non-viral sialidases

    4. XM_006245362.5 → XP_006245424.1  sialidase-2 isoform X1

      See identical proteins and their annotated locations for XP_006245424.1

      UniProtKB/TrEMBL
      A6JWN5, Q5BK97
      Conserved Domains (1) summary
      cd15482
      Location:10 → 367
      Sialidase_non-viral; Non-viral sialidases

    5. XM_017596302.3 → XP_017451791.1  sialidase-2 isoform X1

      UniProtKB/TrEMBL
      A6JWN5, Q5BK97
      Conserved Domains (1) summary
      cd15482
      Location:10 → 367
      Sialidase_non-viral; Non-viral sialidases

    6. XM_006245361.4 → XP_006245423.1  sialidase-2 isoform X1

      See identical proteins and their annotated locations for XP_006245423.1

      UniProtKB/TrEMBL
      A6JWN5, Q5BK97
      Conserved Domains (1) summary
      cd15482
      Location:10 → 367
      Sialidase_non-viral; Non-viral sialidases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64627.1 GenPept UniProtKB/Swiss-Prot:Q64627

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