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    Dnajc2 DnaJ heat shock protein family (Hsp40) member C2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116456, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnajc2provided by RGD
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C2provided by RGD
    Primary source
    RGD:620524
    See related
    EnsemblRapid:ENSRNOG00000012392 AllianceGenome:RGD:620524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zrf2; MIDA1
    Summary
    Predicted to enable several functions, including Hsp70 protein binding activity; ribosome binding activity; and ubiquitin-modified histone reader activity. Involved in negative regulation of cell growth. Predicted to be located in cytoplasm; nuclear membrane; and nucleolus. Predicted to be active in cytosol. Orthologous to human DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 181.9), Testes (RPKM 170.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnajc2 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (14162490..14189662)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (13270239..13297438)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (9881505..9908693)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 26 member 5 Neighboring gene proteasome 26S subunit, ATPase 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene peptidase, mitochondrial processing subunit beta Neighboring gene ADP-ribosylation factor 1, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Immunization with an antigen identified by cytokine tumor vaccine-assisted SEREX (CAS) suppressed growth of the rat 9L glioma in vivo. Okada H, et al. Cancer Res, 2001 Mar 15. PMID 11289140
    2. MIDA1, a protein associated with Id, regulates cell growth. Shoji W, et al. J Biol Chem, 1995 Oct 20. PMID 7559602
    3. The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex. Otto H, et al. Proc Natl Acad Sci U S A, 2005 Jul 19. PMID 16002468, Free PMC Article
    4. Transcriptional activation of polycomb-repressed genes by ZRF1. Richly H, et al. Nature, 2010 Dec 23. PMID 21179169
    5. Identification of novel M phase phosphoproteins by expression cloning. Matsumoto-Taniura N, et al. Mol Biol Cell, 1996 Sep. PMID 8885239, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105894

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-modified histone reader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-modified histone reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-modified histone reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' cotranslational protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' cotranslational protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 2
    Names
    (rat homolog) mouse id-associated protein 1
    DnaJ (Hsp40) homolog, subfamily C, member 2
    gliosarcoma-related antigen MIDA1
    zuotin related factor 2
    zuotin-related factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053776.3 → NP_446228.2  dnaJ homolog subfamily C member 2

      See identical proteins and their annotated locations for NP_446228.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q5HZY5, Q7TQ18, Q7TQ20, Q9WVG4
      UniProtKB/TrEMBL
      A0A0G2JSM0, A6K5A5
      Related
      ENSRNOP00000016909.6, ENSRNOT00000016909.9
      Conserved Domains (5) summary
      smart00717
      Location:553 → 602
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:553 → 600
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00226
      Location:88 → 158
      DnaJ; DnaJ domain
      pfam16717
      Location:349 → 420
      RAC_head; Ribosome-associated complex head domain
      cl20817
      Location:288 → 353
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      14162490..14189662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762628.4 → XP_008760850.1  dnaJ homolog subfamily C member 2 isoform X1

      See identical proteins and their annotated locations for XP_008760850.1

      UniProtKB/Swiss-Prot
      Q5HZY5, Q7TQ18, Q7TQ20, Q9WVG4
      UniProtKB/TrEMBL
      A0A0G2JSM0, A6K5A5
      Conserved Domains (5) summary
      smart00717
      Location:553 → 602
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:553 → 600
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00226
      Location:88 → 158
      DnaJ; DnaJ domain
      pfam16717
      Location:349 → 420
      RAC_head; Ribosome-associated complex head domain
      cl20817
      Location:288 → 353
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQ20.1 GenPept UniProtKB/Swiss-Prot:Q7TQ20

    Gene LinkOut

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