Nabp2 nucleic acid binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nabp2provided by RGD
Official Full Name: nucleic acid binding protein 2provided by RGD
Primary source: RGD:1308158
See related: EnsemblRapid:ENSRNOG00000023480 AllianceGenome:RGD:1308158
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Obfc2b; RGD1308158
Summary: Predicted to enable DNA polymerase binding activity and G-rich strand telomeric DNA binding activity. Predicted to be involved in several processes, including establishment of protein localization to telomere; mitotic G2/M transition checkpoint; and positive regulation of telomere capping. Predicted to be located in chromosome; cytosol; and nucleoplasm. Predicted to be part of SOSS complex. Orthologous to human NABP2 (nucleic acid binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 146.5), Adrenal (RPKM 138.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (1415491..1421113, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (830949..836551, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (2820006..2825627, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables C-rich strand telomeric DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables G-rich strand telomeric DNA binding	IEA Inferred from Electronic Annotation more info
enables G-rich strand telomeric DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of protein localization to telomere	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to telomere	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2/M transition checkpoint	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic G2/M transition checkpoint	IEA Inferred from Electronic Annotation more info
involved_in mitotic G2/M transition checkpoint	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2/M transition checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of telomere capping	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomere capping	ISO Inferred from Sequence Orthology more info
involved_in response to ionizing radiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ionizing radiation	IEA Inferred from Electronic Annotation more info
involved_in response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in response to ionizing radiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SOSS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SOSS complex	IEA Inferred from Electronic Annotation more info
part_of SOSS complex	ISO Inferred from Sequence Orthology more info
part_of SOSS complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in site of double-strand break	IEA Inferred from Electronic Annotation more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SOSS complex subunit B1

Names: SOSS-B1; oligonucleotide/oligosaccharide-binding fold containing 2B; oligonucleotide/oligosaccharide-binding fold-containing protein 2B; sensor of single-strand DNA complex subunit B1; sensor of ssDNA subunit B1; single-stranded DNA-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034939.1 → NP_001030111.2 SOSS complex subunit B1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).

Source sequence(s)

BC104710

UniProtKB/TrEMBL

A0A0G2K954

Related

ENSRNOP00000090943.2, ENSRNOT00000111806.2
NM_001244819.1 → NP_001231748.1 SOSS complex subunit B1 isoform 2

See identical proteins and their annotated locations for NP_001231748.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains different sequence for its 5' end, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

BC104710, DV214819

UniProtKB/Swiss-Prot

Q3SWT1

UniProtKB/TrEMBL

A0A8L2QI91, A6KSD1

Related

ENSRNOP00000036341.5, ENSRNOT00000031362.8

Conserved Domains (2) summary

PRK14971
Location:106 → 187

PRK14971; DNA polymerase III subunit gamma/tau

cd04491
Location:18 → 95

SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

1415491..1421113 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240770.5 → XP_006240832.1 SOSS complex subunit B1 isoform X1

See identical proteins and their annotated locations for XP_006240832.1

UniProtKB/Swiss-Prot

Q3SWT1

UniProtKB/TrEMBL

A0A8L2QI91, A6KSD1

Conserved Domains (2) summary

PRK14971
Location:106 → 187

PRK14971; DNA polymerase III subunit gamma/tau

cd04491
Location:18 → 95

SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
XM_006240769.5 → XP_006240831.1 SOSS complex subunit B1 isoform X1

See identical proteins and their annotated locations for XP_006240831.1

UniProtKB/Swiss-Prot

Q3SWT1

UniProtKB/TrEMBL

A0A8L2QI91, A6KSD1

Conserved Domains (2) summary

PRK14971
Location:106 → 187

PRK14971; DNA polymerase III subunit gamma/tau

cd04491
Location:18 → 95

SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
XM_006240771.5 → XP_006240833.1 SOSS complex subunit B1 isoform X1

See identical proteins and their annotated locations for XP_006240833.1

UniProtKB/Swiss-Prot

Q3SWT1

UniProtKB/TrEMBL

A0A8L2QI91, A6KSD1

Related

ENSRNOP00000088017.2, ENSRNOT00000098497.2

Conserved Domains (2) summary

PRK14971
Location:106 → 187

PRK14971; DNA polymerase III subunit gamma/tau

cd04491
Location:18 → 95

SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
XM_008765029.3 → XP_008763251.1 SOSS complex subunit B1 isoform X1

See identical proteins and their annotated locations for XP_008763251.1

UniProtKB/Swiss-Prot

Q3SWT1

UniProtKB/TrEMBL

A0A8L2QI91, A6KSD1

Conserved Domains (2) summary

PRK14971
Location:106 → 187

PRK14971; DNA polymerase III subunit gamma/tau

cd04491
Location:18 → 95

SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...