Nenf neudesin neurotrophic factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nenfprovided by RGD
Official Full Name: neudesin neurotrophic factorprovided by RGD
Primary source: RGD:1303289
See related: EnsemblRapid:ENSRNOG00000003833 AllianceGenome:RGD:1303289
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Spuf; SCIRP10
Summary: Predicted to enable growth factor activity. Predicted to be involved in negative regulation of appetite. Predicted to act upstream of or within positive regulation of MAPK cascade. Located in endoplasmic reticulum and mitochondrion. Orthologous to human NENF (neudesin neurotrophic factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 352.2), Lung (RPKM 199.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q27

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (105419113..105425911, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (102888004..102894804, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (109990294..109997092, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of appetite	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neudesin

Names: SCIRP10-related protein; Spinal cord injury related protein 10; neuron-derived neurotrophic factor; secreted protein of unknown function; spinal cord injury-related protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.