Pnpla1 patatin-like phospholipase domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pnpla1provided by RGD
Official Full Name: patatin-like phospholipase domain containing 1provided by RGD
Primary source: RGD:1306685
See related: EnsemblRapid:ENSRNOG00000028622 AllianceGenome:RGD:1306685
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable omega-hydroxyceramide transacylase activity and triacylglycerol lipase activity. Predicted to be a structural constituent of skin epidermis. Predicted to be involved in several processes, including establishment of skin barrier; omega-hydroxyceramide biosynthetic process; and triglyceride catabolic process. Predicted to be active in cytoplasm; lipid droplet; and membrane. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 10. Orthologous to human PNPLA1 (patatin like phospholipase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 7.3), Testes (RPKM 3.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (6919689..6953850)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (6917993..6952157)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (6101061..6143762)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH140432 (e-PCR)
- UniSTS:222507

RH140032 (e-PCR)
- UniSTS:222114

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups	ISO Inferred from Sequence Orthology more info
enables omega-hydroxyceramide transacylase activity	ISO Inferred from Sequence Orthology more info
enables structural constituent of skin epidermis	ISO Inferred from Sequence Orthology more info
enables triacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in omega-hydroxyceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: omega-hydroxyceramide transacylase

Names: patatin-like phospholipase domain-containing protein 1

NP_001178770.1

EC 2.3.1.296

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191841.2 → NP_001178770.1 omega-hydroxyceramide transacylase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

D4A3G9

Related

ENSRNOP00000035242.5, ENSRNOT00000033064.9

Conserved Domains (1) summary

cl11396
Location:3 → 373

Patatin_and_cPLA2; Patatins and Phospholipases