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    C1r complement C1r [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312705, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C1rprovided by RGD
    Official Full Name
    complement C1rprovided by RGD
    Primary source
    RGD:1309091
    See related
    EnsemblRapid:ENSRNOG00000011796 AllianceGenome:RGD:1309091
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including calcium ion binding activity; identical protein binding activity; and serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome periodontal type 1. Orthologous to human C1R (complement C1r). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1161.1), Adrenal (RPKM 767.6) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See C1r in Genome Data Viewer
    Location:
    4q42
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159099013..159109770)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157412718..157423483)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157126060..157136825)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553636 Neighboring gene uncharacterized LOC120102383 Neighboring gene complement C1r subcomponent like Neighboring gene uncharacterized LOC102553847 Neighboring gene complement C1s Neighboring gene uncharacterized LOC134486639

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interaction between separated consecutive complement control modules of human C1r: implications for dimerization of the full-length protease. Láng A, et al. FEBS Lett, 2010 Nov 19. PMID 20970424
    2. Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r. Major B, et al. J Biol Chem, 2010 Apr 16. PMID 20178990, Free PMC Article
    3. Alterations of the classic pathway of complement in adipose tissue of obesity and insulin resistance. Zhang J, et al. Am J Physiol Endocrinol Metab, 2007 May. PMID 17244723
    4. The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex. Budayova-Spano M, et al. EMBO J, 2002 Feb 1. PMID 11823416, Free PMC Article
    5. C1R Mutations Trigger Constitutive Complement 1 Activation in Periodontal Ehlers-Danlos Syndrome. Gröbner R, et al. Front Immunol, 2019. PMID 31749804, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular sequestering activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zymogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zymogen activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in blood microparticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement C1r subcomponent
    Names
    complement component 1, r subcomponent
    NP_001128027.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134555.3 → NP_001128027.1  complement C1r subcomponent precursor

      See identical proteins and their annotated locations for NP_001128027.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      B5DEH7, D4A1T6
      Related
      ENSRNOP00000069123.1, ENSRNOT00000078349.3
      Conserved Domains (6) summary
      smart00020
      Location:463 → 699
      Tryp_SPc; Trypsin-like serine protease
      smart00042
      Location:27 → 138
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      cd00190
      Location:464 → 701
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00084
      Location:309 → 371
      Sushi; Sushi repeat (SCR repeat)
      pfam00431
      Location:195 → 302
      CUB; CUB domain
      pfam14670
      Location:161 → 189
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159099013..159109770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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