Acot13 acyl-CoA thioesterase 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acot13provided by RGD
Official Full Name: acyl-CoA thioesterase 13provided by RGD
Primary source: RGD:1306513
See related: EnsemblRapid:ENSRNOG00000018415 AllianceGenome:RGD:1306513
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Them2
Summary: Predicted to enable fatty acyl-CoA hydrolase activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and protein homotetramerization. Predicted to be located in mitochondrial matrix. Orthologous to human ACOT13 (acyl-CoA thioesterase 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 685.0), Muscle (RPKM 414.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (40668404..40680876)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (40240378..40252851)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (42241141..42253611)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acyl-coenzyme A thioesterase 13

Names: thioesterase superfamily member 2

NP_001099581.1

EC 3.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106111.1 → NP_001099581.1 acyl-coenzyme A thioesterase 13

See identical proteins and their annotated locations for NP_001099581.1

Status: PROVISIONAL

Source sequence(s)

CH474064

UniProtKB/TrEMBL

A6KLF5, D3ZA93

Related

ENSRNOP00000024878.5, ENSRNOT00000024878.8

Conserved Domains (1) summary

cd03443
Location:28 → 138

PaaI_thioesterase; PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not ...