Cidea cell death-inducing DFFA-like effector a [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cideaprovided by RGD
Official Full Name: cell death-inducing DFFA-like effector aprovided by RGD
Primary source: RGD:1305106
See related: EnsemblRapid:ENSRNOG00000018505 AllianceGenome:RGD:1305106
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable lipid transfer activity; phosphatidic acid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including lipid droplet fusion; negative regulation of cold-induced thermogenesis; and negative regulation of tumor necrosis factor production. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in mitochondrial envelope and nucleus. Predicted to be active in lipid droplet. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CIDEA (cell death inducing DFFA like effector a). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 747.3), Adrenal (RPKM 604.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (63164817..63190384)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (60894917..60920485)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (63082861..63108450)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cell death-associated lipid droplet protein CIDE-A is a noncanonical marker of endoplasmic reticulum stress.
Title: Cell death-associated lipid droplet protein CIDE-A is a noncanonical marker of endoplasmic reticulum stress.
These results suggest that acute cold exposure resulted in down-regulation of CIDEA in interscapular brown adipose tissue by sympathetically activated beta(3)-adrenoreceptor-mediated mechanisms in rats.
Title: Acute cold exposure-induced down-regulation of CIDEA, cell death-inducing DNA fragmentation factor-alpha-like effector A, in rat interscapular brown adipose tissue by sympathetically activated beta3-adrenoreceptors.

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General gene information

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Markers

D18Got62 (e-PCR)
- UniSTS:112724

RH128852 (e-PCR)
- UniSTS:212160

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lipid transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to cold	ISO Inferred from Sequence Orthology more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in lipid droplet fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sequestering of triglyceride	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic DNA fragmentation	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to stilbenoid	ISO Inferred from Sequence Orthology more info
involved_in temperature homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in mitochondrial envelope	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lipid transferase CIDEA

Names: cell death activator CIDE-A; cell death-inducing DNA fragmentation factor, alpha subunit-like effector A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170467.1 → NP_001163938.1 lipid transferase CIDEA

Status: VALIDATED

Source sequence(s)

BF284899, CR462136, FM041444

UniProtKB/TrEMBL

A0A8I6AJS6

Related

ENSRNOP00000095439.2, ENSRNOT00000110214.2

Conserved Domains (1) summary

cd06539
Location:33 → 110

CIDE_N_A; CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

63164817..63190384

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096669.2 → XP_038952597.1 lipid transferase CIDEA isoform X1

UniProtKB/TrEMBL

A0A8I5Y2E9

Related

ENSRNOP00000078103.1, ENSRNOT00000112497.2

Conserved Domains (1) summary

cd06539
Location:76 → 153

CIDE_N_A; CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin ...
XM_039096670.2 → XP_038952598.1 lipid transferase CIDEA isoform X2

UniProtKB/TrEMBL

A0A8I6AJS6

Conserved Domains (1) summary

cd06539
Location:25 → 102

CIDE_N_A; CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin ...