Gigyf2 GRB10 interacting GYF protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gigyf2provided by RGD
Official Full Name: GRB10 interacting GYF protein 2provided by RGD
Primary source: RGD:2318130
See related: EnsemblRapid:ENSRNOG00000023577 AllianceGenome:RGD:2318130
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable molecular adaptor activity and proline-rich region binding activity. Predicted to be involved in negative regulation of type I interferon-mediated signaling pathway; post-transcriptional regulation of gene expression; and rescue of stalled ribosome. Predicted to act upstream of or within several processes, including insulin-like growth factor receptor signaling pathway; mitotic G1 DNA damage checkpoint signaling; and spinal cord motor neuron differentiation. Predicted to be located in several cellular components, including cytoplasmic stress granule; perikaryon; and proximal dendrite. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GIGYF2 (GRB10 interacting GYF protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 151.9), Kidney (RPKM 148.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q35

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (95449143..95574927)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (88001212..88127040)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (94425191..94550431)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138626 (e-PCR)
- UniSTS:220713

RH131801 (e-PCR)
- UniSTS:215084

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables proline-rich region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within feeding behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
involved_in insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in mRNA destabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic G1 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within musculoskeletal movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in perikaryon	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in proximal dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in proximal dendrite	ISO Inferred from Sequence Orthology more info
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GRB10-interacting GYF protein 2

Names: PERQ amino acid-rich with GYF domain-containing protein 2; rCG23949-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427666.1 → NP_001414595.1 GRB10-interacting GYF protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I5ZS67, A6JWM3

Related

ENSRNOP00000068457.3, ENSRNOT00000076099.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

95449143..95574927

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084707.2 → XP_038940635.1 GRB10-interacting GYF protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZS67, A6JWM3

Conserved Domains (2) summary

PRK10811
Location:311 → 497

rne; ribonuclease E; Reviewed

cd00072
Location:534 → 589

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_063266510.1 → XP_063122580.1 GRB10-interacting GYF protein 2 isoform X2

UniProtKB/TrEMBL

A6JWM3
XM_039084708.2 → XP_038940636.1 GRB10-interacting GYF protein 2 isoform X2

UniProtKB/TrEMBL

A6JWM3

Conserved Domains (2) summary

PRK10811
Location:305 → 491

rne; ribonuclease E; Reviewed

cd00072
Location:528 → 583

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_063266516.1 → XP_063122586.1 GRB10-interacting GYF protein 2 isoform X7

UniProtKB/TrEMBL

A0A096MKC0
XM_063266511.1 → XP_063122581.1 GRB10-interacting GYF protein 2 isoform X3

UniProtKB/TrEMBL

A6JWM4

Related

ENSRNOP00000068141.3, ENSRNOT00000075967.3
XM_063266513.1 → XP_063122583.1 GRB10-interacting GYF protein 2 isoform X4

UniProtKB/TrEMBL

A0A096MJI4, A6JWM4
XM_063266509.1 → XP_063122579.1 GRB10-interacting GYF protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZS67, A6JWM3
XM_063266512.1 → XP_063122582.1 GRB10-interacting GYF protein 2 isoform X3

UniProtKB/TrEMBL

A6JWM4
XM_063266514.1 → XP_063122584.1 GRB10-interacting GYF protein 2 isoform X4

UniProtKB/TrEMBL

A0A096MJI4, A6JWM4

Related

ENSRNOP00000080015.2, ENSRNOT00000120312.2
XM_063266508.1 → XP_063122578.1 GRB10-interacting GYF protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZS67, A6JWM3
XM_039084710.2 → XP_038940638.1 GRB10-interacting GYF protein 2 isoform X5

UniProtKB/TrEMBL

A6JWM6

Conserved Domains (2) summary

PRK10811
Location:218 → 404

rne; ribonuclease E; Reviewed

cd00072
Location:441 → 496

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_039084711.2 → XP_038940639.1 GRB10-interacting GYF protein 2 isoform X6

UniProtKB/TrEMBL

A6JWM7

Conserved Domains (2) summary

PRK10811
Location:156 → 342

rne; ribonuclease E; Reviewed

cd00072
Location:379 → 434

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_039084714.2 → XP_038940642.1 GRB10-interacting GYF protein 2 isoform X9

UniProtKB/TrEMBL

A6JWM7

Conserved Domains (2) summary

PHA03169
Location:105 → 272

PHA03169; hypothetical protein; Provisional

cd00072
Location:309 → 364

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_039084713.2 → XP_038940641.1 GRB10-interacting GYF protein 2 isoform X8

UniProtKB/TrEMBL

A6JWM7

Conserved Domains (2) summary

PHA03169
Location:111 → 278

PHA03169; hypothetical protein; Provisional

cd00072
Location:315 → 370

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_039084718.2 → XP_038940646.1 GRB10-interacting GYF protein 2 isoform X10

UniProtKB/TrEMBL

A6JWM7

Conserved Domains (2) summary

PHA03169
Location:81 → 248

PHA03169; hypothetical protein; Provisional

cd00072
Location:285 → 340

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_039084719.2 → XP_038940647.1 GRB10-interacting GYF protein 2 isoform X10

UniProtKB/TrEMBL

A6JWM7

Conserved Domains (2) summary

PHA03169
Location:81 → 248

PHA03169; hypothetical protein; Provisional

cd00072
Location:285 → 340

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.