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    Uba3 ubiquitin-like modifier activating enzyme 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117553, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uba3provided by RGD
    Official Full Name
    ubiquitin-like modifier activating enzyme 3provided by RGD
    Primary source
    RGD:621084
    See related
    EnsemblRapid:ENSRNOG00000006221 AllianceGenome:RGD:621084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ube1c
    Summary
    Enables NEDD8 activating enzyme activity and nuclear receptor binding activity. Involved in negative regulation of DNA-templated transcription. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBA3 (ubiquitin like modifier activating enzyme 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 288.5), Adrenal (RPKM 235.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uba3 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (131346219..131367378, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (129789526..129810707, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (129548411..129569550, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene TATA element modulatory factor 1 Neighboring gene uncharacterized LOC120102348 Neighboring gene ARF like GTPase 6 interacting protein 5 Neighboring gene leiomodin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice. Tateishi K, et al. J Cell Biol, 2001 Nov 12. PMID 11696557, Free PMC Article
    2. Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. Bohnsack RN, et al. J Biol Chem, 2003 Jul 18. PMID 12740388
    3. The activating enzyme of NEDD8 inhibits steroid receptor function. Fan M, et al. Mol Endocrinol, 2002 Feb. PMID 11818503
    4. The mechanism of poly-NEDD8 chain formation in vitro. Ohki Y, et al. Biochem Biophys Res Commun, 2009 Apr 10. PMID 19245792
    5. Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. Gong L, et al. J Biol Chem, 1999 Apr 23. PMID 10207026

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. activating enzyme of NEDD8 inhibits steroid receptor function
      Title: The activating enzyme of NEDD8 inhibits steroid receptor function.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NEDD8 activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NEDD8 activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NEDD8 activating enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to NEDD8 activating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NEDD8 activating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endomitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endomitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein neddylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein neddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein neddylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NEDD8-activating enzyme E1 catalytic subunit
    Names
    NEDD8-activating enzyme E1C
    ubiquitin-activating enzyme 3
    ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)
    NP_476553.1
    XP_006236998.1
    XP_063141501.1
    XP_063141502.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057205.2 → NP_476553.1  NEDD8-activating enzyme E1 catalytic subunit

      See identical proteins and their annotated locations for NP_476553.1

      Status: VALIDATED

      Source sequence(s)
      BC081743
      UniProtKB/Swiss-Prot
      Q99MI7
      UniProtKB/TrEMBL
      A0A8L2Q4P8, A6IBF6
      Related
      ENSRNOP00000008893.9, ENSRNOT00000008893.9
      Conserved Domains (2) summary
      cd01488
      Location:71 → 368
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam08825
      Location:376 → 461
      E2_bind; E2 binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      131346219..131367378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236936.5 → XP_006236998.1  NEDD8-activating enzyme E1 catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q4P8
      Related
      ENSRNOP00000108517.1, ENSRNOT00000133425.1
      Conserved Domains (2) summary
      cd01488
      Location:57 → 354
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam08825
      Location:362 → 447
      E2_bind; E2 binding domain

    2. XM_063285431.1 → XP_063141501.1  NEDD8-activating enzyme E1 catalytic subunit isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q4P8
      Related
      ENSRNOP00000086883.1, ENSRNOT00000117124.2

    3. XM_063285432.1 → XP_063141502.1  NEDD8-activating enzyme E1 catalytic subunit isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MI7.1 GenPept UniProtKB/Swiss-Prot:Q99MI7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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