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    Pgd phosphogluconate dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 110208, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pgdprovided by MGI
    Official Full Name
    phosphogluconate dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:97553
    See related
    Ensembl:ENSMUSG00000028961 AllianceGenome:MGI:97553
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610042A05Rik
    Summary
    Enables phosphogluconate dehydrogenase (decarboxylating) activity. Involved in pentose-phosphate shunt, oxidative branch. Acts upstream of or within pentose biosynthetic process. Is active in cytosol. Is expressed in several structures, including adrenal gland; alimentary system; axial musculature; liver; and orbito-sphenoid. Orthologous to human PGD (phosphogluconate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 156.7), mammary gland adult (RPKM 135.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pgd in Genome Data Viewer
    Location:
    4 E2; 4 78.96 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149234448..149251162, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149149991..149166705, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4730 Neighboring gene STARR-positive B cell enhancer ABC_E11279 Neighboring gene STARR-positive B cell enhancer ABC_E4731 Neighboring gene ribosomal protein SA, pseudogene 12 Neighboring gene STARR-seq mESC enhancer starr_12104 Neighboring gene centromere protein S Neighboring gene STARR-positive B cell enhancer ABC_E3554 Neighboring gene kinesin family member 1B Neighboring gene STARR-positive B cell enhancer ABC_E845 Neighboring gene ubiquitination factor E4B, opposite strand 3 Neighboring gene ubiquitination factor E4B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADP binding  
    enables NADP binding  
    enables NADP binding  
    enables carbohydrate binding  
    enables carboxylic acid binding  
    enables phosphogluconate dehydrogenase (decarboxylating) activity  
    enables phosphogluconate dehydrogenase (decarboxylating) activity PubMed 
    enables phosphogluconate dehydrogenase (decarboxylating) activity  
    enables phosphogluconate dehydrogenase (decarboxylating) activity  
    Component Evidence Code Pubs
    is_active_in cytosol  
    is_active_in cytosol PubMed 

    General protein information

    Preferred Names
    6-phosphogluconate dehydrogenase, decarboxylating
    NP_001074743.1
    NP_001343261.1
    XP_006538535.1
    XP_030108942.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081274.2NP_001074743.1  6-phosphogluconate dehydrogenase, decarboxylating isoform 1

      See identical proteins and their annotated locations for NP_001074743.1

      Status: VALIDATED

      Source sequence(s)
      AI834806, AK145602, CX212251, CX215938
      Consensus CDS
      CCDS38974.1
      UniProtKB/Swiss-Prot
      Q3UD80, Q9DCD0
      UniProtKB/TrEMBL
      Q91V28
      Related
      ENSMUSP00000081141.7, ENSMUST00000084124.7
      Conserved Domains (3) summary
      PRK09287
      Location:14470
      PRK09287; 6-phosphogluconate dehydrogenase; Validated
      pfam00393
      Location:180469
      6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain
      pfam03446
      Location:3176
      NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
    2. NM_001356332.1NP_001343261.1  6-phosphogluconate dehydrogenase, decarboxylating isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI834806, AK145602, AL731655, CX212251
      Conserved Domains (1) summary
      pfam00393
      Location:1285
      6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      149234448..149251162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253082.2XP_030108942.1  6-phosphogluconate dehydrogenase, decarboxylating isoform X1

      Conserved Domains (1) summary
      pfam00393
      Location:1285
      6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain
    2. XM_006538472.4XP_006538535.1  6-phosphogluconate dehydrogenase, decarboxylating isoform X1

      Conserved Domains (1) summary
      pfam00393
      Location:1285
      6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain

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