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    Zdhhc1 zinc finger, DHHC domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 70796, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zdhhc1provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 1provided by MGI
    Primary source
    MGI:MGI:1918046
    See related
    Ensembl:ENSMUSG00000039199 AllianceGenome:MGI:1918046
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DHHC-1; 4432412D04Rik
    Summary
    Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of defense response to virus by host. Acts upstream of or within protein palmitoylation. Located in endosome membrane. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; heart; and lung. Orthologous to human ZDHHC1 (zinc finger DHHC-type containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 28.6), ovary adult (RPKM 27.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zdhhc1 in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106199055..106223694, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105472419..105497062, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 36 Neighboring gene tubulin polymerization-promoting protein family member 3 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene hydroxysteroid 11-beta dehydrogenase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DHHC domain: a new highly conserved cysteine-rich motif. Putilina T, et al. Mol Cell Biochem, 1999 May. PMID 10395086
    2. The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Zhou Q, et al. Cell Host Microbe, 2014 Oct 8. PMID 25299331
    3. Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation. Nie L, et al. Mol Cell, 2024 Sep 5. PMID 39173637
    4. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. Oku S, et al. J Biol Chem, 2013 Jul 5. PMID 23687301, Free PMC Article
    5. Identification of PSD-95 palmitoylating enzymes. Fukata M, et al. Neuron, 2004 Dec 16. PMID 15603741

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
      Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antiviral innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to endosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein oligomerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC1
    Names
    probable palmitoyltransferase ZDHHC1
    zinc finger DHHC domain-containing protein 1
    NP_001344181.1
    NP_001365935.1
    NP_001365936.1
    NP_001365937.1
    NP_001365938.1
    NP_001365939.1
    NP_001365940.1
    NP_780369.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357252.2 → NP_001344181.1  palmitoyltransferase ZDHHC1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variant 5, encodes isoform 2.
      Source sequence(s)
      AC090480, AC151573
      UniProtKB/TrEMBL
      B7ZMY5
      Conserved Domains (1) summary
      pfam01529
      Location:126 → 281
      DHHC; DHHC palmitoyltransferase

    2. NM_001379006.1 → NP_001365935.1  palmitoyltransferase ZDHHC1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 1 and 4, encodes isoform 1.
      Source sequence(s)
      AC090480, AC151573
      UniProtKB/Swiss-Prot
      Q0VE36, Q8BJ24, Q8R0N9
      Conserved Domains (1) summary
      pfam01529
      Location:126 → 281
      DHHC; DHHC palmitoyltransferase

    3. NM_001379007.1 → NP_001365936.1  palmitoyltransferase ZDHHC1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 1 and 3, encodes isoform 1.
      Source sequence(s)
      AC090480, AC151573
      UniProtKB/Swiss-Prot
      Q0VE36, Q8BJ24, Q8R0N9
      Conserved Domains (1) summary
      pfam01529
      Location:126 → 281
      DHHC; DHHC palmitoyltransferase

    4. NM_001379008.1 → NP_001365937.1  palmitoyltransferase ZDHHC1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC090480, AC151573
      UniProtKB/TrEMBL
      B7ZMY5
      Conserved Domains (1) summary
      pfam01529
      Location:126 → 281
      DHHC; DHHC palmitoyltransferase

    5. NM_001379009.1 → NP_001365938.1  palmitoyltransferase ZDHHC1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 7 and 8, encodes isoform 3.
      Source sequence(s)
      AC090480, AC151573
      Conserved Domains (1) summary
      pfam01529
      Location:126 → 281
      DHHC; DHHC palmitoyltransferase

    6. NM_001379010.1 → NP_001365939.1  palmitoyltransferase ZDHHC1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 6 and 8, encodes isoform 3.
      Source sequence(s)
      AC090480, AC151573
      Conserved Domains (1) summary
      pfam01529
      Location:126 → 281
      DHHC; DHHC palmitoyltransferase

    7. NM_001379011.1 → NP_001365940.1  palmitoyltransferase ZDHHC1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 6 and 7, encodes isoform 3.
      Source sequence(s)
      AC090480, AC151573
      Conserved Domains (1) summary
      pfam01529
      Location:126 → 281
      DHHC; DHHC palmitoyltransferase

    8. NM_175160.5 → NP_780369.1  palmitoyltransferase ZDHHC1 isoform 1

      See identical proteins and their annotated locations for NP_780369.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AC090480, AC151573
      Consensus CDS
      CCDS22603.1
      UniProtKB/Swiss-Prot
      Q0VE36, Q8BJ24, Q8R0N9
      Related
      ENSMUSP00000148381.2, ENSMUST00000212303.2
      Conserved Domains (1) summary
      pfam01529
      Location:126 → 281
      DHHC; DHHC palmitoyltransferase

    RNA

    1. NR_166407.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090480, AC151573

    2. NR_166408.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090480, AC151573

    3. NR_166409.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090480, AC151573

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106199055..106223694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0N9.2 GenPept UniProtKB/Swiss-Prot:Q8R0N9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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