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    Ankk1 ankyrin repeat and kinase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 244859, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ankk1provided by MGI
    Official Full Name
    ankyrin repeat and kinase domain containing 1provided by MGI
    Primary source
    MGI:MGI:3045301
    See related
    Ensembl:ENSMUSG00000032257 AllianceGenome:MGI:3045301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9930020N01Rik
    Summary
    Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and protein serine kinase activity. Acts upstream of or within regulation of cell cycle process. Located in cell projection; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and skeletal musculature. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; alexithymia; drug dependence (multiple); and mild cognitive impairment. Orthologous to human ANKK1 (ankyrin repeat and kinase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Ankk1 in Genome Data Viewer
    Location:
    9 A5.3; 9 26.83 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (49326494..49338341, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (49415194..49427041, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 4894 Neighboring gene STARR-seq mESC enhancer starr_24090 Neighboring gene STARR-seq mESC enhancer starr_24091 Neighboring gene dopamine receptor D2 Neighboring gene predicted gene, 46111 Neighboring gene STARR-seq mESC enhancer starr_24092 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:49297299-49297500 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:49297697-49297806 Neighboring gene tetratricopeptide repeat domain 12 Neighboring gene neural cell adhesion molecule 1 Neighboring gene predicted gene 11149

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ANKK1 gene associated with addictions is expressed in astroglial cells and upregulated by apomorphine. Hoenicka J, et al. Biol Psychiatry, 2010 Jan 1. PMID 19853839
    2. ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism. Rubio-Solsona E, et al. PLoS One, 2018. PMID 29758057, Free PMC Article
    3. The Addiction-Related Protein ANKK1 is Differentially Expressed During the Cell Cycle in Neural Precursors. España-Serrano L, et al. Cereb Cortex, 2017 May 1. PMID 27166167
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ankyrin repeat and protein kinase domain-containing protein 1
    NP_001363880.1
    NP_766510.1
    XP_036010896.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376951.1 → NP_001363880.1  ankyrin repeat and protein kinase domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC167980
      UniProtKB/TrEMBL
      B7ZN83
      Conserved Domains (4) summary
      PHA02876
      Location:364 → 694
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:403 → 434
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:672 → 742
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:37 → 305
      PKc_like; Protein Kinases, catalytic domain

    2. NM_172922.4 → NP_766510.1  ankyrin repeat and protein kinase domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_766510.1

      Status: VALIDATED

      Source sequence(s)
      AC167980
      Consensus CDS
      CCDS40616.1
      UniProtKB/Swiss-Prot
      Q8BZ25
      Related
      ENSMUSP00000034792.6, ENSMUST00000034792.7
      Conserved Domains (4) summary
      PHA02876
      Location:333 → 693
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:402 → 433
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:671 → 741
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:37 → 305
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      49326494..49338341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155003.1 → XP_036010896.1  ankyrin repeat and protein kinase domain-containing protein 1 isoform X1

      Conserved Domains (4) summary
      PHA02876
      Location:286 → 646
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:355 → 386
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:624 → 694
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:28 → 258
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZ25.1 GenPept UniProtKB/Swiss-Prot:Q8BZ25

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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