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    Uri1 URI1, prefoldin-like chaperone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308537, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Uri1provided by RGD
    Official Full Name
    URI1, prefoldin-like chaperoneprovided by RGD
    Primary source
    RGD:1310358
    See related
    EnsemblRapid:ENSRNOG00000014463 AllianceGenome:RGD:1310358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310358
    Summary
    Predicted to enable several functions, including RNA polymerase II complex binding activity; phosphatase inhibitor activity; and transcription corepressor activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway; and negative regulation of phosphatase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RPAP3/R2TP/prefoldin-like complex. Orthologous to human URI1 (URI1 prefoldin like chaperone). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 170.9), Muscle (RPKM 161.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uri1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (99783157..99845787, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (90646392..90704811, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (94346513..94404362, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 536 Neighboring gene uncharacterized LOC134485112 Neighboring gene U6 spliceosomal RNA Neighboring gene mitochondrial ribosomal protein L32, pseudogene 1 Neighboring gene cyclin E1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. Dorjsuren D, et al. Mol Cell Biol, 1998 Dec. PMID 9819440, Free PMC Article
    2. Subcellular localization of RPB5-mediating protein and its putative functional partner. Delgermaa L, et al. Mol Cell Biol, 2004 Oct. PMID 15367675, Free PMC Article
    3. Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). Wei W, et al. Cell Res, 2003 Apr. PMID 12737519
    4. Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP. Mita P, et al. Mol Cell Biol, 2011 Sep. PMID 21730289, Free PMC Article
    5. S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. Djouder N, et al. Mol Cell, 2007 Oct 12. PMID 17936702

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to steroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RPAP3/R2TP/prefoldin-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    unconventional prefoldin RPB5 interactor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107507.2 → NP_001100977.1  unconventional prefoldin RPB5 interactor 1 isoform 1

      See identical proteins and their annotated locations for NP_001100977.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AGP6, A6JAE1, D4A234
      Related
      ENSRNOP00000019463.4, ENSRNOT00000019463.7
      Conserved Domains (1) summary
      cl09111
      Location:27 → 145
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    2. NM_001428660.1 → NP_001415589.1  unconventional prefoldin RPB5 interactor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    3. NM_001428661.1 → NP_001415590.1  unconventional prefoldin RPB5 interactor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    4. NM_001428662.1 → NP_001415591.1  unconventional prefoldin RPB5 interactor 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    5. NM_001428666.1 → NP_001415595.1  unconventional prefoldin RPB5 interactor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    6. NM_001428669.1 → NP_001415598.1  unconventional prefoldin RPB5 interactor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    7. NM_001428670.1 → NP_001415599.1  unconventional prefoldin RPB5 interactor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    8. NM_001428671.1 → NP_001415600.1  unconventional prefoldin RPB5 interactor 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    9. NM_001428674.1 → NP_001415603.1  unconventional prefoldin RPB5 interactor 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A6M3

    10. NM_001428676.1 → NP_001415605.1  unconventional prefoldin RPB5 interactor 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      99783157..99845787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261707.1 → XP_063117777.1  unconventional prefoldin RPB5 interactor 1 isoform X1

      Related
      ENSRNOP00000086643.1, ENSRNOT00000101126.2

    2. XM_063261710.1 → XP_063117780.1  unconventional prefoldin RPB5 interactor 1 isoform X2

      Related
      ENSRNOP00000092940.2, ENSRNOT00000110109.2

    3. XM_039111759.2 → XP_038967687.1  unconventional prefoldin RPB5 interactor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGP6
      Conserved Domains (1) summary
      cl09111
      Location:1 → 71
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    Nucleotide Protein Strain
    Heading Accession and Version

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