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    PRE6 proteasome core particle subunit alpha 4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854119, updated on 9-Dec-2024

    Summary

    Official Symbol
    PRE6
    Official Full Name
    proteasome core particle subunit alpha 4
    Primary source
    SGD:S000005398
    Locus tag
    YOL038W
    See related
    AllianceGenome:SGD:S000005398; FungiDB:YOL038W; VEuPathDB:YOL038W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in several cellular components, including mitochondrion; nuclear outer membrane-endoplasmic reticulum membrane network; and proteasome storage granule. Part of proteasome core complex, alpha-subunit complex. Orthologous to human PSMA7 (proteasome 20S subunit alpha 7) and PSMA8 (proteasome 20S subunit alpha 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See PRE6 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (255337..256101)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein P2A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome core complex, alpha-subunit complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome core complex, alpha-subunit complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in proteasome storage granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proteasome core particle subunit alpha 4
    NP_014604.1
    • Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      255337..256101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183292.1NP_014604.1  TPA: proteasome core particle subunit alpha 4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014604.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W229, P40303
      UniProtKB/TrEMBL
      A6ZNH1, B3LJ21, B5VRL3, C7GK06, C8ZHS7, G2WMJ5, N1NWR3
      Conserved Domains (1) summary
      cd03755
      Location:4215
      proteasome_alpha_type_7; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...