U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG5001 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33308, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG5001provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031322
    Locus tag
    Dmel_CG5001
    See related
    AllianceGenome:FB:FBgn0031322
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5001
    Summary
    Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be active in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital myopathy 21. Orthologous to several human genes including DNAJB5 (DnaJ heat shock protein family (Hsp40) member B5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG5001 in Genome Data Viewer
    Location:
    21F2-21F2; 2-2 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1185757..1196807)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1185757..1196807)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA-guanine transglycosylase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates. Deo A, et al. Sci Rep, 2024 Sep 6. PMID 39242711, Free PMC Article
    2. Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110. Kuo Y, et al. Cell Death Dis, 2013 Oct 3. PMID 24091676, Free PMC Article
    3. Protein interactions on telomeric retrotransposons in Drosophila. Takács S, et al. Int J Biol Sci, 2012. PMID 22949888, Free PMC Article
    4. The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster. Tsou WL, et al. Neurobiol Dis, 2015 Oct. PMID 26007638, Free PMC Article
    5. Evidence for large domains of similarly expressed genes in the Drosophila genome. Spellman PT, et al. J Biol, 2002. PMID 12144710, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates.
      Title: Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG5001-PA
    CG5001-PB
    CG5001-PC
    CG5001-PD

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1185757..1196807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258903.1 → NP_001245832.1  uncharacterized protein Dmel_CG5001, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245832.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPY9
      Conserved Domains (3) summary
      cd10747
      Location:174 → 338
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 347
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:4 → 65
      DnaJ; DnaJ domain

    2. NM_001272932.1 → NP_001259861.1  uncharacterized protein Dmel_CG5001, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259861.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPY9
      Conserved Domains (3) summary
      cd10747
      Location:174 → 338
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 347
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:4 → 65
      DnaJ; DnaJ domain

    3. NM_001258904.2 → NP_001245833.1  uncharacterized protein Dmel_CG5001, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245833.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NCP5
      Conserved Domains (3) summary
      cd10747
      Location:170 → 334
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 343
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:4 → 65
      DnaJ; DnaJ domain

    4. NM_134742.4 → NP_608586.2  uncharacterized protein Dmel_CG5001, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608586.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPY9
      Conserved Domains (3) summary
      cd10747
      Location:174 → 338
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 347
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:4 → 65
      DnaJ; DnaJ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NCP5 M9NCP5
    Q5BIK1 Q5BIK1
    Q9VPY9 Q9VPY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools