Fitm Fat storage inducing transmembrane protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Fitmprovided by FlyBase
Official Full Name: Fat storage inducing transmembrane proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0035586
Locus tag: Dmel_CG10671
See related: AllianceGenome:FB:FBgn0035586
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10671; Dmel\CG10671; FIT2; i136
Summary: Predicted to enable coenzyme A diphosphatase activity. Involved in several processes, including adult locomotory behavior; regulation of dendrite development; and sensory perception of sound. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Used to study Siddiqi syndrome and lipid metabolism disorder. Human ortholog(s) of this gene implicated in Siddiqi syndrome. Orthologous to several human genes including FITM2 (fat storage inducing transmembrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (5144082..5146063, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (5137182..5139163, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables coenzyme A diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables coenzyme A diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty-acyl-CoA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid droplet formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid droplet organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid droplet organization	IEA Inferred from Electronic Annotation more info
involved_in lipid droplet organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid storage	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sequestering of triglyceride	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain