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    Naxe NAD(P)HX epimerase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31944, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Naxeprovided by FlyBase
    Official Full Name
    NAD(P)HX epimeraseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030178
    Locus tag
    Dmel_CG2974
    See related
    AllianceGenome:FB:FBgn0030178
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2974; Dmel\CG2974
    Summary
    Predicted to enable NAD(P)HX epimerase activity. Predicted to be involved in metabolite repair. Predicted to be located in cytosol and mitochondrion. Is expressed in organism. Orthologous to several human genes including NAXE (NAD(P)HX epimerase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Naxe in Genome Data Viewer
    Location:
    9B1-9B1; 1-31 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10084914..10086171, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9978947..9980204, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45602 Neighboring gene ZAP3 Neighboring gene uncharacterized protein Neighboring gene RhoU Neighboring gene antisense RNA:CR44894 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sensitivity of the distribution of mutational fitness effects to environment, genetic background, and adaptedness: a case study with Drosophila. Wang AD, et al. Evolution, 2014 Mar. PMID 24206451
    2. Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. Weber AL, et al. PLoS One, 2012. PMID 22496853, Free PMC Article
    3. The carnegie protein trap library: a versatile tool for Drosophila developmental studies. Buszczak M, et al. Genetics, 2007 Mar. PMID 17194782, Free PMC Article
    4. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article
    5. Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila. Meltzer H, et al. Nat Commun, 2019 May 8. PMID 31068592, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD(P)HX epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD(P)HX epimerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in metabolite repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NAD(P)HX epimerase
    Names
    CG2974-PB
    Naxe-PB
    NP_572604.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10084914..10086171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132376.2 → NP_572604.2  NAD(P)HX epimerase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572604.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B6IDS2, Q8SX11, Q9W2Y3
      Conserved Domains (1) summary
      cl00318
      Location:3 → 230
      YjeF_N; YjeF-related protein N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2Y3.2 Q9W2Y3

    Gene LinkOut

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