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    Pis Phosphatidylinositol synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32506, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pisprovided by FlyBase
    Official Full Name
    Phosphatidylinositol synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030670
    Locus tag
    Dmel_CG9245
    See related
    AllianceGenome:FB:FBgn0030670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO02059370.38; CG9245; Dmel\CG9245; dpis; dPis; dPIS; PIS
    Summary
    Enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity. Involved in basement membrane organization and phototransduction. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including adult head; adult heart; central brain primordium; eye; and ganglia. Used to study chromosome 16p11.2 deletion syndrome, 593-kb. Orthologous to human CDIPT (CDP-diacylglycerol--inositol 3-phosphatidyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pis in Genome Data Viewer
    Location:
    13E8-13E8; 1-51 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15701451..15703770, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15595484..15597803, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Huntingtin-associated protein 40 kDa Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduced expression of CDP-DAG synthase changes lipid composition and leads to male sterility in Drosophila. Laurinyecz B, et al. Open Biol, 2016 Jan. PMID 26791243, Free PMC Article
    2. A phosphoinositide synthase required for a sustained light response. Wang T, et al. J Neurosci, 2006 Dec 6. PMID 17151285, Free PMC Article
    3. CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway. Liu Y, et al. PLoS Genet, 2014 Mar. PMID 24603715, Free PMC Article
    4. Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen. Vacaru AM, et al. J Biol Chem, 2013 Apr 19. PMID 23449981, Free PMC Article
    5. Stratum, a Homolog of the Human GEF Mss4, Partnered with Rab8, Controls the Basal Restriction of Basement Membrane Proteins in Epithelial Cells. Devergne O, et al. Cell Rep, 2017 Feb 21. PMID 28228250, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pis regulates the polarized deposition of basement membrane proteins.
      Title: Polarized deposition of basement membrane proteins depends on Phosphatidylinositol synthase and the levels of Phosphatidylinositol 4,5-bisphosphate.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in basement membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol synthase
    Names
    CG9245-PA
    CG9245-PB
    PI synthase
    Phosphatidyl-inositol synthase
    Pis-PA
    Pis-PB
    drosophila phosphatidylinositol synthase
    NP_573055.1
    NP_727878.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15701451..15703770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132827.3 → NP_573055.1  phosphatidylinositol synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573055.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F3YDD4, Q8IR29, Q8SX37, Q9VXR7
      Related
      FBpp0073874
      Conserved Domains (1) summary
      pfam01066
      Location:13 → 75
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    2. NM_167456.3 → NP_727878.1  phosphatidylinositol synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727878.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9YHX2
      Related
      FBpp0073875
      Conserved Domains (1) summary
      pfam01066
      Location:13 → 63
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SX37.1 Q8SX37

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