Gbeta13F G protein beta subunit 13F [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gbeta13Fprovided by FlyBase
Official Full Name: G protein beta subunit 13Fprovided by FlyBase
Primary source: FLYBASE:FBgn0001105
Locus tag: Dmel_CG10545
See related: AllianceGenome:FB:FBgn0001105
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Liang-1.22; CG10545; clone 1.22; dgbeta; Dmel\CG10545; G b13F; G protein &bgr; G-beta; G-betab; Gb13F; Gbb; Gbeta; Gbeta13; gbeta13F; GNB1/2/3/4 like; G[[beta13F]]; G[[beta]]
Summary: Predicted to enable signaling receptor complex adaptor activity. Involved in several processes, including cell adhesion involved in heart morphogenesis; gastrulation; and mesectoderm development. Located in plasma membrane. Part of heterotrimeric G-protein complex. Is expressed in several structures, including brain; embryonic/larval midgut primordium; organism subdivision; sensory nervous system primordium; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease dominant intermediate F; artery disease (multiple); autosomal dominant intellectual developmental disorder 42; congenital stationary night blindness 1H; and hematologic cancer (multiple). Orthologous to several human genes including GNB1 (G protein subunit beta 1) and GNB4 (G protein subunit beta 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 13F16-13F16; 1-52 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15860115..15866175)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (15754148..15760208)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that G-oalpha47A and Gbeta13F cooperate with Ggamma1 to maintain cardiac integrity in Drosophila.
Title: Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila.
Pins can mediate asymmetric spindle geometry.[PINs]. Comparisons of the phenotypes of Galphai, Ric-8, Gbeta13Fsingle and Ric-8;Gbeta13F double loss-of-function mutants indicate that, in NBs, Ric-8 positively regulates Gai activity.
Title: Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in apical protein localization	TAS Traceable Author Statement more info	PubMed
involved_in asymmetric neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion involved in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cytoskeleton polarity involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesectoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myosin II filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: G protein beta subunit 13F

Names: CG10545-PA; CG10545-PC; CG10545-PE; CG10545-PF; CG10545-PG; CG10545-PH; G protein beta subunit; G protein beta-subunit 13F; G-protein beta 13F; G[[beta]] brain; Gbeta13F-PA; Gbeta13F-PC; Gbeta13F-PE; Gbeta13F-PF; Gbeta13F-PG; Gbeta13F-PH

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

15860115..15866175

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206739.2 → NP_996462.1 G protein beta subunit 13F, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996462.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P26308, Q9VXM8

UniProtKB/TrEMBL

A4V4I0

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
NM_206736.2 → NP_996459.1 G protein beta subunit 13F, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996459.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P26308, Q9VXM8

UniProtKB/TrEMBL

A4V4I0

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
NM_206737.2 → NP_996460.1 G protein beta subunit 13F, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996460.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P26308, Q9VXM8

UniProtKB/TrEMBL

A4V4I0

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
NM_206738.3 → NP_996461.1 G protein beta subunit 13F, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996461.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P26308, Q9VXM8

UniProtKB/TrEMBL

A4V4I0

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
NM_080351.7 → NP_525090.1 G protein beta subunit 13F, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_525090.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P26308, Q9VXM8

UniProtKB/TrEMBL

A4V4I0

Related

FBpp0073921

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
NM_001316638.2 → NP_001303567.1 G protein beta subunit 13F, isoform H [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P26308, Q9VXM8

UniProtKB/TrEMBL

A4V4I0

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]