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    Myb Myb oncogene-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32543, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mybprovided by FlyBase
    Official Full Name
    Myb oncogene-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002914
    Locus tag
    Dmel_CG9045
    See related
    AllianceGenome:FB:FBgn0002914
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-myb; c-Myb; CG9045; D-myb; Dm myb; Dm Myb; Dm-myb; Dm-Myb; Dmel\CG9045; dmMYB; DmMyb; DmMYB; dmyb; dMyb; Dmyb; DMyb; l(1)XVI; myb; MYB; p85
    Summary
    Enables DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including eggshell chorion gene amplification; microtubule cytoskeleton organization; and negative regulation of cell size. Located in euchromatin. Part of DRM complex and Myb complex. Is active in nucleus. Is expressed in several structures, including brain; female germline cell; gonad; larval central nervous system; and ventral nerve cord. Orthologous to several human genes including MYBL1 (MYB proto-oncogene like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Myb in Genome Data Viewer
    Location:
    13F14-13F14; 1-52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15854832..15857823, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15748865..15751856, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene stunted Neighboring gene Ubiquitin like 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene AlkB Neighboring gene G protein beta subunit 13F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MYB transcription factors in plants. Martin C, et al. Trends Genet, 1997 Feb. PMID 9055608
    2. Molecular evolution of the Myb family of transcription factors: evidence for polyphyletic origin. Rosinski JA, et al. J Mol Evol, 1998 Jan. PMID 9419227
    3. Drosophila and vertebrate myb proteins share two conserved regions, one of which functions as a DNA-binding domain. Peters CW, et al. EMBO J, 1987 Oct. PMID 3121304, Free PMC Article
    4. Isolation of the proto-oncogene c-myb from D. melanogaster. Katzen AL, et al. Cell, 1985 Jun. PMID 3921261
    5. Individual repeats of Drosophila Myb can function in transformation by v-Myb. Bin X, et al. J Virol, 1993 Dec. PMID 8230457, Free PMC Article

    See all (144) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Dm-Myb Oncoprotein Contributes to Insulator Function and Stabilizes Repressive H3K27me3 PcG Domains.
      Title: The Dm-Myb Oncoprotein Contributes to Insulator Function and Stabilizes Repressive H3K27me3 PcG Domains.
    2. Data show that L(3)mbt chromosomal targeting requires proteins of a site-specific DNA binding complex Myb-MuvB (MMB core component Mip130)/DREAM.
      Title: Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment.
    3. Myb transcriptionally regulates cytokinesis.
      Title: The complex containing Drosophila Myb and RB/E2F2 regulates cytokinesis in a histone H2Av-dependent manner.
    4. Dm myb and grim are both involved in regulating PCD in two distinct settings suggests that these two genes may often work together to mediate PCD.
      Title: The dREAM/Myb-MuvB complex and Grim are key regulators of the programmed death of neural precursor cells at the Drosophila posterior wing margin.
    5. the Lin-52 and Myb proteins counteract the repressive activities of the other members of the MMB/dREAM complex at specific genomic loci in a developmentally controlled manner
      Title: Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex.
    6. Dampened transcriptional activation by E2F1-DP and Myb-MuvB is important to repress mitosis and coordinate the endocycle transcription.
      Title: Dampened activity of E2F1-DP and Myb-MuvB transcription factors in Drosophila endocycling cells.
    7. Cell cycle specific degradation of Drosophila Myb is likely to be utilized as a key regulatory mechanism in down-regulating the activity of the Myb complex.
      Title: Two components of the Myb complex, DMyb and Mip130, are specifically associated with euchromatin and degraded during prometaphase throughout development.
    8. Thease results demonstrate epigenetic regulation of gene expression by Myb, and E2F2-RBF in vivo, and also provide an explanation for the ability of Mip130-null mutants to rescue the lethality of Myb-null mutants in vivo.
      Title: Epigenetic regulation of gene expression by Drosophila Myb and E2F2-RBF via the Myb-MuvB/dREAM complex.
    9. The essential roles of Myb are executed as part of a switching mechanism that is dependent on DNA sites and developmental context.
      Title: Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells.
    10. Role for a Drosophila Myb-containing protein complex in site-specific DNA replication
      Title: Role for a Drosophila Myb-containing protein complex in site-specific DNA replication.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eggshell chorion gene amplification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eggshell chorion gene amplification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DRM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Myb complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Myb oncogene-like
    Names
    CG9045-PA
    CG9045-PB
    CG9045-PD
    CG9045-PE
    Myb-PA
    Myb-PB
    Myb-PD
    Myb-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15854832..15857823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206733.2 → NP_996456.1  Myb oncogene-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996456.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P04197, Q9VXM9
      UniProtKB/TrEMBL
      Q53YG3
      Conserved Domains (4) summary
      smart00717
      Location:136 → 184
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:188 → 233
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam09316
      Location:388 → 530
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:139 → 197
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    2. NM_206734.2 → NP_996457.1  Myb oncogene-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996457.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P04197, Q9VXM9
      UniProtKB/TrEMBL
      Q53YG3
      Conserved Domains (4) summary
      smart00717
      Location:136 → 184
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:188 → 233
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam09316
      Location:388 → 530
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:139 → 197
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    3. NM_078615.4 → NP_511170.1  Myb oncogene-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511170.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P04197, Q9VXM9
      UniProtKB/TrEMBL
      Q53YG3
      Related
      FBpp0073961
      Conserved Domains (4) summary
      smart00717
      Location:136 → 184
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:188 → 233
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam09316
      Location:388 → 530
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:139 → 197
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    4. NM_206731.2 → NP_996454.1  Myb oncogene-like, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996454.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P04197, Q9VXM9
      UniProtKB/TrEMBL
      Q53YG3
      Conserved Domains (4) summary
      smart00717
      Location:136 → 184
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:188 → 233
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam09316
      Location:388 → 530
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:139 → 197
      Myb_DNA-bind_6; Myb-like DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04197.2 P04197
    Q53YG3 Q53YG3

    Gene LinkOut

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