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    Ugt35A1 UDP-glycosyltransferase family 35 member A1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41334, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ugt35A1provided by FlyBase
    Official Full Name
    UDP-glycosyltransferase family 35 member A1provided by FlyBase
    Primary source
    FLYBASE:FBgn0026315
    Locus tag
    Dmel_CG6644
    See related
    AllianceGenome:FB:FBgn0026315
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AC 006491F; CG6644; Dmel\CG6644; DmeUgt35a; UDPGT1; ugt35a; Ugt35a; UGT35A1; Ugt86Df
    Summary
    Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in glycosylation. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; leg; and third segment of antenna. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ugt35A1 in Genome Data Viewer
    Location:
    86D5-86D5; 3-50 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11170817..11172664, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6996539..6998386, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase family 35 member E2 Neighboring gene UDP-glycosyltransferase family 35 member B1 Neighboring gene UDP-glycosyltransferase family 304 member A1 Neighboring gene UDP-glycosyltransferase family 303 member A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preferential expression of biotransformation enzymes in the olfactory organs of Drosophila melanogaster, the antennae. Wang Q, et al. J Biol Chem, 1999 Apr 9. PMID 10187818
    2. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Gilchrist DA, et al. Cell, 2010 Nov 12. PMID 21074046, Free PMC Article
    3. Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cross population. Marriage TN, et al. Genetics, 2014 Sep. PMID 25236448, Free PMC Article
    4. Drosophila P elements preferentially transpose to replication origins. Spradling AC, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21896744, Free PMC Article
    5. Insect glycobiology: a lectin multigene family in Drosophila melanogaster. Theopold U, et al. Biochem Biophys Res Commun, 1999 Aug 11. PMID 10441526

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UDP-glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glycosyltransferase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables UDP-glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycosylation ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-glycosyltransferase family 35 member A1
    Names
    CG6644-PA
    UDP-glycosyltransferase 35a
    Ugt35A1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11170817..11172664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079590.3 → NP_524314.2  UDP-glycosyltransferase family 35 member A1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524314.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGS9, Q9XYN4
      Related
      FBpp0081850
      Conserved Domains (2) summary
      PHA03392
      Location:19 → 474
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:55 → 526
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGS9 Q9VGS9
    Q9XYN4 Q9XYN4

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