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    Not1 Not1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740252, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Not1provided by FlyBase
    Official Full Name
    Not1provided by FlyBase
    Primary source
    FLYBASE:FBgn0085436
    Locus tag
    Dmel_CG34407
    See related
    AllianceGenome:FB:FBgn0085436
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.29; anon-WO0118547.221; CG1874; CG1884; CG34407; clone 1.29; Dmel\CG34407; NOT; not1; NOT1
    Old locus tag
    CG1874; CG1884; Dmel_CG1874; Dmel_CG1884
    Summary
    Predicted to enable molecular adaptor activity. Involved in follicle cell of egg chamber development; negative regulation of translation; and nuclear-transcribed mRNA poly(A) tail shortening. Located in cytosol. Part of CCR4-NOT complex. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and ganglia. Used to study Vissers-Bodmer syndrome and heart disease. Human ortholog(s) of this gene implicated in Vissers-Bodmer syndrome and holoprosencephaly 12. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Not1 in Genome Data Viewer
    Location:
    45F1-45F4; 2-61 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9566146..9579007, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5453651..5466512, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45281 Neighboring gene Odorant receptor 45b Neighboring gene Alkaline phosphatase 6 Neighboring gene long non-coding RNA:CR46257 Neighboring gene 5' nucleotidase C Neighboring gene SET and MYND domain containing, class 4, member 1 Neighboring gene Uroporphyrinogen decarboxylase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and assembly of the NOT10:11 module of the CCR4-NOT complex. Levdansky Y, et al. Commun Biol, 2023 Jul 17. PMID 37460791, Free PMC Article
    2. Regulation of the Drosophila transcriptome by Pumilio and the CCR4-NOT deadenylase complex. Haugen RJ, et al. RNA, 2024 Jun 17. PMID 38627019,
    3. Defining an evolutionarily conserved role of GW182 in circular RNA degradation. Jia R, et al. Cell Discov, 2019. PMID 31636958, Free PMC Article
    4. Rapid Gene Evolution in an Ancient Post-transcriptional and Translational Regulatory System Compensates for Meiotic X Chromosomal Inactivation. Xia S, et al. Mol Biol Evol, 2022 Jan 7. PMID 34626117, Free PMC Article
    5. Silencing of CCR4-NOT complex subunits affects heart structure and function. Elmén L, et al. Dis Model Mech, 2020 Jul 20. PMID 32471864, Free PMC Article

    See all (115) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CCR4-NOT complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Not1
    Names
    CG34407-PC
    CG34407-PD
    CG34407-PE
    CG34407-PF
    CG34407-PG
    CG34407-PH
    Not1-PC
    Not1-PD
    Not1-PE
    Not1-PF
    Not1-PG
    Not1-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9566146..9579007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165678.4 → NP_724798.3  Not1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724798.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY81
      Conserved Domains (5) summary
      pfam04054
      Location:2123 → 2472
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:1500 → 1643
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:1149 → 1367
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:900 → 1073
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:576 → 731
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

    2. NM_001103773.3 → NP_001097243.1  Not1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097243.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY80
      Conserved Domains (5) summary
      pfam04054
      Location:2121 → 2470
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:1500 → 1643
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:1149 → 1367
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:900 → 1073
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:576 → 731
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

    3. NM_001103772.3 → NP_001097242.1  Not1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097242.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY81
      Conserved Domains (5) summary
      pfam04054
      Location:2123 → 2472
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:1500 → 1643
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:1149 → 1367
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:900 → 1073
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:576 → 731
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

    4. NM_001103774.3 → NP_001097244.1  Not1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097244.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY82
      Conserved Domains (5) summary
      pfam04054
      Location:1838 → 2187
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:1215 → 1358
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:864 → 1082
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:615 → 788
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:291 → 446
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

    5. NM_001299323.1 → NP_001286252.1  Not1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286252.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEZ3
      Conserved Domains (5) summary
      pfam04054
      Location:2129 → 2478
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:1506 → 1649
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:1155 → 1373
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:906 → 1079
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:582 → 737
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

    6. NM_001169628.2 → NP_001163099.1  Not1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163099.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QCN4
      Conserved Domains (5) summary
      pfam04054
      Location:2123 → 2472
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:1500 → 1643
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:1149 → 1367
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:900 → 1073
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:576 → 731
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LEZ3 A0A0B4LEZ3
    A8DY80 A8DY80
    A8DY81 A8DY81
    A8DY82 A8DY82
    E2QCN4 E2QCN4
    Q8IH39 Q8IH39
    Q95TG6 Q95TG6

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