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    Hinfp Histone H4 transcription factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47718, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hinfpprovided by FlyBase
    Official Full Name
    Histone H4 transcription factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025635
    Locus tag
    Dmel_CG17829
    See related
    AllianceGenome:FB:FBgn0025635
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17829; Dmel\CG17829; EG:115C2.6
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in gonad and organism. Orthologous to human HINFP (histone H4 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hinfp in Genome Data Viewer
    Location:
    1B12-1B12; 1-0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (625542..628016)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (519575..522049)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting 37A Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45475 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L36 Neighboring gene MYB binding protein 1a Neighboring gene Death related ced-3/Nedd2-like caspase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cytological F1 RNAi screen for defects in Drosophila melanogaster female meiosis. Gilliland WD, et al. Genetics, 2024 May 7. PMID 38531678,
    2. Histone locus bodies: a paradigm for how nuclear biomolecular condensates control cell cycle regulated gene expression. Geisler MS, et al. Nucleus, 2023 Dec. PMID 38095604, Free PMC Article
    3. Hinfp is a guardian of the somatic genome by repressing transposable elements. Nirala NK, et al. Proc Natl Acad Sci U S A, 2021 Oct 12. PMID 34620709, Free PMC Article
    4. Identification of genes expressed during Drosophila melanogaster gastrulation by using subtractive hybridization. González-Agüero M, et al. Gene, 2005 Jan 31. PMID 15716118
    5. A Genetic Screen for Genes That Impact Peroxisomes in Drosophila Identifies Candidate Genes for Human Disease. Graves HK, et al. G3 (Bethesda), 2020 Jan 7. PMID 31767637, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    histone H4 transcription factor
    Names
    CG17829-PA
    CG17829-PB
    CG17829-PC
    Hinfp-PA
    Hinfp-PB
    Hinfp-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      625542..628016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143797.3 → NP_652054.1  histone H4 transcription factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652054.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77260
      Related
      FBpp0070111
      Conserved Domains (1) summary
      sd00017
      Location:237 → 257
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_166852.3 → NP_726685.1  histone H4 transcription factor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726685.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W5E6
      Related
      FBpp0070112
      Conserved Domains (1) summary
      sd00017
      Location:218 → 238
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_166851.3 → NP_726684.1  histone H4 transcription factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726684.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77260
      Related
      FBpp0070113
      Conserved Domains (1) summary
      sd00017
      Location:237 → 257
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77260 O77260
    Q9W5E6 Q9W5E6

    Gene LinkOut

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