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    Urm1 Ubiquitin-related modifier 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Urm1provided by FlyBase
    Official Full Name
    Ubiquitin-related modifier 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0053276
    Locus tag
    Dmel_CG33276
    See related
    AllianceGenome:FB:FBgn0053276
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-AE003558.1; CG33276; Dmel\CG33276
    Summary
    Predicted to enable protein tag activity. Involved in negative regulation of JNK cascade. Located in cytoplasm. Is expressed in organism. Orthologous to human URM1 (ubiquitin related modifier 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Urm1 in Genome Data Viewer
    Location:
    66A8-66A8; 3-21 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7639811..7640446, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7632911..7633546, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Puratrophin-1-like Neighboring gene long non-coding RNA:CR45866 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Peptidoglycan recognition protein SD Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The HTLV-1 oncoprotein Tax is modified by the ubiquitin related modifier 1 (Urm1). Hleihel R, et al. Retrovirology, 2018 Apr 17. PMID 29665857, Free PMC Article
    2. A proteomics approach to identify targets of the ubiquitin-like molecule Urm1 in Drosophila melanogaster. Khoshnood B, et al. PLoS One, 2017. PMID 28953965, Free PMC Article
    3. Urm1: an essential regulator of JNK signaling and oxidative stress in Drosophila melanogaster. Khoshnood B, et al. Cell Mol Life Sci, 2016 May. PMID 26715182, Free PMC Article
    4. A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation. Pirone L, et al. Sci Rep, 2017 Jan 18. PMID 28098257, Free PMC Article
    5. Drosophila as a Model for Infectious Diseases. Harnish JM, et al. Int J Mol Sci, 2021 Mar 8. PMID 33800390, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein urmylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA thio-modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin-related modifier 1
    Names
    CG33276-PB
    Ubiquitin-related modifier 1 ortholog
    Urm1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7639811..7640446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206296.3 → NP_996018.2  Ubiquitin-related modifier 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996018.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E6X7, C1C595, Q7KU86
      Conserved Domains (1) summary
      pfam09138
      Location:7 → 101
      Urm1; Urm1 (Ubiquitin related modifier)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KU86.2 Q7KU86

    Gene LinkOut

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