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    Fkbp39 FK506-binding protein 39kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41860, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fkbp39provided by FlyBase
    Official Full Name
    FK506-binding protein 39kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013269
    Locus tag
    Dmel_CG6226
    See related
    AllianceGenome:FB:FBgn0013269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6226; Dmel\CG6226; FK506-bp1; FK506bp1; fkbp39; FKbp39; FKBP39; IFK506-bp1
    Summary
    Enables FK506 binding activity and juvenile hormone response element binding activity. Involved in juvenile hormone mediated signaling pathway and negative regulation of macroautophagy. Located in heterochromatin. Is expressed in several structures, including embryonic/larval midgut primordium; gonad; gut section; head epidermis primordium; and somatic trunk mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Fkbp39 in Genome Data Viewer
    Location:
    88F1-88F1; 3-57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15331584..15333133, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11157306..11158855, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene easter Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene Cytoplasmic FMR1 interacting protein Neighboring gene N-acetylglucosamine kinase Neighboring gene Seryl-tRNA synthetase, mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FKBP39, a Drosophila member of a family of proteins that bind the immunosuppressive drug FK506. Theopold U, et al. Gene, 1995 Apr 24. PMID 7538962
    2. Nucleoplasmin-like domain of FKBP39 from Drosophila melanogaster forms a tetramer with partly disordered tentacle-like C-terminal segments. Kozłowska M, et al. Sci Rep, 2017 Jan 11. PMID 28074868, Free PMC Article
    3. Molecular determinants of Drosophila immunophilin FKBP39 nuclear localization. Orłowski M, et al. Biol Chem, 2018 Apr 25. PMID 29337690
    4. FKBP39 Controls the Larval Stage JH Activity and Development in Drosophila melanogaster. Wang X, et al. Insects, 2022 Mar 28. PMID 35447772, Free PMC Article
    5. Nuclear immunophilin FKBP39 from Drosophila melanogaster drives spontaneous liquid-liquid phase separation. Tarczewska A, et al. Int J Biol Macromol, 2020 Nov 15. PMID 32615218

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila.
      Title: FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila.
    2. Nuclear immunophilin FKBP39 from Drosophila melanogaster drives spontaneous liquid-liquid phase separation.
      Title: Nuclear immunophilin FKBP39 from Drosophila melanogaster drives spontaneous liquid-liquid phase separation.
    3. The results show that FKBP39 possesses a specific nuclear localization signal (NLS) in close proximity to a putative helix-turn-helix (HTH) motif and FKBP39 may bind DNA in vivo and in vitro.
      Title: Molecular determinants of Drosophila immunophilin FKBP39 nuclear localization.
    4. Analyses of full-length FKBP39 and its isolated NPL domain suggested that the distal regions of the polypeptide chain influence and determine the quaternary conformation of the nucleoplasmin-like protein.
      Title: Nucleoplasmin-like domain of FKBP39 from Drosophila melanogaster forms a tetramer with partly disordered tentacle-like C-terminal segments.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables FK506 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables juvenile hormone response element binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in juvenile hormone mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FK506-binding protein 39kD
    Names
    CG6226-PA
    FK506 binding protein-1
    FK506-binding protein 1
    FK506-binding protein of 39 kDa
    Fkbp39-PA
    NP_524364.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15331584..15333133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079640.3 → NP_524364.2  FK506-binding protein 39kD [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524364.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54397, Q9VF88
      Related
      FBpp0082574
      Conserved Domains (1) summary
      pfam00254
      Location:262 → 354
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54397.2 P54397

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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