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    Dna2 DNA replication helicase/nuclease 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31934, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dna2provided by FlyBase
    Official Full Name
    DNA replication helicase/nuclease 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0288690
    Locus tag
    Dmel_CG2990
    See related
    AllianceGenome:FB:FBgn0288690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2990; DmDNA2; Dmel\CG2990; DNA2; l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107; mus109
    Summary
    Predicted to enable 5'-3' DNA helicase activity; 5'-flap endonuclease activity; and RNA binding activity. Predicted to be involved in DNA double-strand break processing; DNA replication, Okazaki fragment processing; and replication fork reversal. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in organism and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dna2 in Genome Data Viewer
    Location:
    9A4-9A4; 1-30 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10010481..10014279)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9904514..9908312)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chitinase 6 Neighboring gene antisense RNA:CR45185 Neighboring gene Yolk protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Mutagen-Sensitivity Gene mus109 Encodes DmDNA2. Mitchell C, et al. Genes (Basel), 2022 Feb 7. PMID 35205357, Free PMC Article
    2. Isolation of two X-linked mutants in Drosophila melanogaster which are sensitive to gamma-rays. Nguyen TD, et al. Mutat Res, 1978 Jan. PMID 414131
    3. The maxillary palp of Drosophila: ultrastructure and physiology depends on the lozenge gene. Riesgo-Escovar JR, et al. J Comp Physiol A, 1997 Feb. PMID 9011067
    4. Mutagen sensitivity of Drosophila melanogaster. III. X-linked loci governing sensitivity to methyl methanesulfonate. Smith PD. Mol Gen Genet, 1976 Nov 24. PMID 189178
    5. The effects of mutagen-sensitive mutants of Drosophila melanogaster in nonmutagenized cells. Baker BS, et al. Genetics, 1979 Jul. PMID 119665, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-3' DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-flap endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA double-strand break processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in DNA replication, Okazaki fragment processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in replication fork reversal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA replication helicase/nuclease 2
    Names
    CG2990-PB
    CG2990-PC
    DNA helicase
    Dna2-PB
    Dna2-PC
    mutagen-sensitive 109
    NP_001096933.1
    NP_727386.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10010481..10014279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167214.2 → NP_727386.1  DNA replication helicase/nuclease 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727386.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH96, Q8IRL9
      Related
      FBpp0071350
      Conserved Domains (5) summary
      TIGR00376
      Location:480 → 1069
      TIGR00376; DNA helicase, putative
      pfam08696
      Location:99 → 297
      Dna2; DNA replication factor Dna2
      pfam13087
      Location:815 → 1055
      AAA_12; AAA domain
      cl00641
      Location:283 → 415
      Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4
      cl21455
      Location:636 → 859
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001103463.2 → NP_001096933.1  DNA replication helicase/nuclease 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096933.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH96, Q9W2Z4
      Conserved Domains (5) summary
      TIGR00376
      Location:479 → 1068
      TIGR00376; DNA helicase, putative
      pfam08696
      Location:99 → 296
      Dna2; DNA replication factor Dna2
      pfam13087
      Location:814 → 1054
      AAA_12; AAA domain
      cl00641
      Location:282 → 414
      Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4
      cl21455
      Location:635 → 858
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86D36 Q86D36
    Q8IRL9 Q8IRL9
    Q9W2Z4 Q9W2Z4

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